Assessment of the potential genotoxic risk of medicinal Tamarindus indica fruit pulp extract using in vivo assays

Autor(es)

Silva, F. M. V. ^[1] ; Leite, M. F. ^[2] ; Spadaro, A. C. C. ^[2] ; Uyemura, S. A. ^[3] ; Maistro, E. L. ^[4]

Afiliação do(s) autor(es)

^[1] Univ Jose do Rosario Vellano, Genet Lab, Alfenas, MG - Brazil

^[2] Univ Sao Paulo, Dept Quim & Fis, Fac Ciencias Farmaceut, BR-14049 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut, BR-14049 Ribeirao Preto, SP - Brazil

^[4] Univ Estadual Paulista, Dept Fonoaudiol, Fac Filosofia & Ciencias, Marilia, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Genetics and Molecular Research; v. 8, n. 3, p. 1085-1092, 2009.
• Citações Web of Science: 3

Resumo

Tamarindus indica has been used in folk medicine as an antidiabetic, a digestive aid, and a carminative, among other uses. Currently, there is no information in the toxicology literature concerning the safety of T. indica extract. We evaluated the clastogenic and/or genotoxic potential of fruit pulp extract of this plant in vivo in peripheral blood and liver cells of Wistar rats, using the comet assay, and in bone marrow cells of Swiss mice, using the micronucleus test. The extract was administered by gavage at doses of 1000, 1500 and 2000 mg/kg body weight. Peripheral blood and liver cells from Wistar rats were collected 24 h after treatment, for the comet assay. The micronucleus test was carried out in bone marrow cells from Swiss mice collected 24 h after treatment. The extract made with T. indica was devoid of clastogenic and genotoxic activities in the cells of the rodents, when administered orally at these three acute doses. (AU)

• Processo FAPESP: 06/57514-2 - Avaliacao do potencial mutagenico dos extratos de clusia alata e psidium cattleyanum em celulas de roedores in vivo.
• Beneficiário: Edson Luis Maistro
• Modalidade de apoio: Auxílio à Pesquisa - Regular