Myeloperoxidase as Inflammatory Marker of Periodontal Disease: Experimental Study in Rats

Autor(es)

Gomes, Debora A. S. ^[1] ; Pires, Juliana R. ^[2] ; Zuza, Elizangela P. ^[2] ; Muscara, Marcelo N. ^[3] ; Herrera, Bruno S. ^[3] ; Spolidorio, Luis C. ^[4] ; Toledo, Benedicto E. C. ^[2] ; Spolidorio, Denise M. P. ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Diag & Oral Surg, Sao Paulo - Brazil

^[2] Educ Fdn Barretos, Dept Periodont, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Pharmacol, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Pathol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: IMMUNOLOGICAL INVESTIGATIONS; v. 38, n. 2, p. 117-122, 2009.
• Citações Web of Science: 18

Resumo

Rationale: Previous studies have used myeloperoxidase (MPO) as an inflammatory marker to estimate the accumulation of neutrophils in inflamed regions. Objective: The aim of this experimental study was to quantify the levels of MPO related to experimental periodontal disease in rats. Methods: Periodontal disease was induced in a group of rats using placement of a ligature around molar teeth. A group of rats without ligature placement served as a control. Measurements were made on the 3rd, 7th, 15th and 30th day from baseline. Gingival tissues were taken for quantification of MPO levels by ELISA. Results: The rats with induced periodontal disease showed statistically higher MPO levels (p 0.05) when compared to control rats. A significant increase in the levels of MPO released on days 7 and 30 was observed, with higher levels in the group with induced periodontitis. Conclusion: The levels of MPO were found to be higher in rats with induced periodontal disease, confirming the hypothesis that MPO may serve as an inflammatory marker for periodontitis. (AU)

• Processo FAPESP: 04/09849-0 - Influência do Diabetes Mellitus na microbiota e na dinâmica do processo inflamatório na periodontite induzida em ratos
• Beneficiário: Denise Madalena Palomari Spolidorio
• Modalidade de apoio: Auxílio à Pesquisa - Regular