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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Myeloperoxidase as Inflammatory Marker of Periodontal Disease: Experimental Study in Rats

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Author(s):
Gomes, Debora A. S. [1] ; Pires, Juliana R. [2] ; Zuza, Elizangela P. [2] ; Muscara, Marcelo N. [3] ; Herrera, Bruno S. [3] ; Spolidorio, Luis C. [4] ; Toledo, Benedicto E. C. [2] ; Spolidorio, Denise M. P. [4]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Dept Diag & Oral Surg, Sao Paulo - Brazil
[2] Educ Fdn Barretos, Dept Periodont, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Pharmacol, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Pathol, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: IMMUNOLOGICAL INVESTIGATIONS; v. 38, n. 2, p. 117-122, 2009.
Web of Science Citations: 18
Abstract

Rationale: Previous studies have used myeloperoxidase (MPO) as an inflammatory marker to estimate the accumulation of neutrophils in inflamed regions. Objective: The aim of this experimental study was to quantify the levels of MPO related to experimental periodontal disease in rats. Methods: Periodontal disease was induced in a group of rats using placement of a ligature around molar teeth. A group of rats without ligature placement served as a control. Measurements were made on the 3rd, 7th, 15th and 30th day from baseline. Gingival tissues were taken for quantification of MPO levels by ELISA. Results: The rats with induced periodontal disease showed statistically higher MPO levels (p 0.05) when compared to control rats. A significant increase in the levels of MPO released on days 7 and 30 was observed, with higher levels in the group with induced periodontitis. Conclusion: The levels of MPO were found to be higher in rats with induced periodontal disease, confirming the hypothesis that MPO may serve as an inflammatory marker for periodontitis. (AU)