Role of immunoexpression of nitric oxide synthases by Hodgkin and Reed-Sternberg cells on apoptosis deregulation and on clinical outcome of classical Hodgkin lymphoma

Autor(es)

Campos, Antonio H. J. F. M. ^[1] ; Aldred, Vera L. ^[2] ; Ribeiro, Karina C. B. ^[3] ; Vassallo, Jos ^{[1, 4]} ; Soares, Fernando A. ^[1]

Afiliação do(s) autor(es)

^[1] AC Camargo Canc Treatment & Res Ctr, Dept Pathol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Dept Pathol, Sao Paulo - Brazil

^[3] AC Camargo Canc Treatment & Res Ctr, Canc Registry, Sao Paulo - Brazil

^[4] Univ Estadual Campinas, Lab Investigat & Mol Pathol, Sch Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Molecular and Cellular Biochemistry; v. 321, n. 1-2, p. 95-102, JAN 2009.
• Citações Web of Science: 16

Resumo

Hodgkin and Reed-Sternberg (H-RS) cells of classical Hodgkin lymphoma (cHL) present an impaired expression of immunoglobulin genes, but escape apoptotic death. We investigated whether nitric oxide synthases (NOS) are expressed by H-RS cells, studied their association with EBV status and the expression of apoptotic proteins, and investigated their relationship to the clinical outcome of 171 patients. NOS1 and NOS2 were expressed in a large number of cases, whereas NOS3 expression was not detected. Positive associations were found between NOS1 and p53, bax and NOS2, bcl-2 and NOS2, bax and p53, and between bax and fasL. Inverse correlations were established between EBV and NOS2 and between EBV and bcl-2. A shorter overall survival (OS) was associated with strong expression of NOS2. In conclusion, NOS are expressed by H-RS cells of cHL. (AU)

• Processo FAPESP: 03/06989-2 - A relacao entre a expressao de sintases do oxido nitrico por celulas de reed-sternberg, imunossupressao e infeccao pelo virus de epstein-barr no linfoma de hodgkin.
• Beneficiário: Fernando Augusto Soares
• Modalidade de apoio: Auxílio à Pesquisa - Regular