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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Role of immunoexpression of nitric oxide synthases by Hodgkin and Reed-Sternberg cells on apoptosis deregulation and on clinical outcome of classical Hodgkin lymphoma

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Author(s):
Campos, Antonio H. J. F. M. [1] ; Aldred, Vera L. [2] ; Ribeiro, Karina C. B. [3] ; Vassallo, Jos [1, 4] ; Soares, Fernando A. [1]
Total Authors: 5
Affiliation:
[1] AC Camargo Canc Treatment & Res Ctr, Dept Pathol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Dept Pathol, Sao Paulo - Brazil
[3] AC Camargo Canc Treatment & Res Ctr, Canc Registry, Sao Paulo - Brazil
[4] Univ Estadual Campinas, Lab Investigat & Mol Pathol, Sch Med, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Molecular and Cellular Biochemistry; v. 321, n. 1-2, p. 95-102, JAN 2009.
Web of Science Citations: 16
Abstract

Hodgkin and Reed-Sternberg (H-RS) cells of classical Hodgkin lymphoma (cHL) present an impaired expression of immunoglobulin genes, but escape apoptotic death. We investigated whether nitric oxide synthases (NOS) are expressed by H-RS cells, studied their association with EBV status and the expression of apoptotic proteins, and investigated their relationship to the clinical outcome of 171 patients. NOS1 and NOS2 were expressed in a large number of cases, whereas NOS3 expression was not detected. Positive associations were found between NOS1 and p53, bax and NOS2, bcl-2 and NOS2, bax and p53, and between bax and fasL. Inverse correlations were established between EBV and NOS2 and between EBV and bcl-2. A shorter overall survival (OS) was associated with strong expression of NOS2. In conclusion, NOS are expressed by H-RS cells of cHL. (AU)