Pimarane-type Diterpenes: Antimicrobial Activity against Oral Pathogens

Autor(es):Mostrar menos -

Porto, Thiago S. ^[1] ; Rangel, Rander ^[1] ; Furtado, Niege A. J. C. ^[2] ; de Carvalho, Tatiane C. ^[1] ; Martins, Carlos H. G. ^[1] ; Veneziani, Rodrigo C. S. ^[1] ; Da Costa, Fernando B. ^[2] ; Vinholis, Adriana H. C. ^[1] ; Cunha, Wilson R. ^[1] ; Heleno, Vladimir C. G. ^[1] ; Ambrosio, Sergio R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Franca, Nucleo Pesquisa Ciencias Exatas & Tecnol, Franca, SP - Brazil

^[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, BR-14049 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Molecules; v. 14, n. 1, p. 191-199, JAN 2009.
• Citações Web of Science: 68

Resumo

Seven pimarane type-diterpenes re-isolated from Viguiera arenaria Baker and two semi-synthetic pimarane derivatives were evaluated in vitro against the following main microorganisms responsible for dental caries: Streptococcus salivarius, S. sobrinus, S. mutans, S. mitis, S. sanguinis and Lactobacillus casei. The compounds ent-pimara-8(14), 15-dien-19-oic acid (PA); ent-8(14), 15-pimaradien-3 beta-ol; ent-15-pimarene-8 beta, 19-diol; ent-8(14), 15-pimaradien-3 beta-acetoxy and the sodium salt derivative of PA were the most active compounds, displaying MIC values ranging from 2 to 8 mu g.mL(-1). Thus, this class of compounds seems promising as a class of new effective anticariogenic agents. Furthermore, our results also allow us to conclude that minor structural differences among these diterpenes significantly influence their antimicrobial activity, bringing new perspectives to the discovery of new natural compounds that could be employed in the development of oral care products. (AU)

• Processo FAPESP: 07/54762-8 - Obtenção de análogos estruturais do ácido pimaradienóico através do processo de biotransformação fúngica e estudo do efeito destes metabólitos sobre a atividade da enzima TcDHODH e sobre a contração da musculatura lisa vascular de artéria aorta de ratos
• Beneficiário: Sergio Ricardo Ambrosio
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Jovens Pesquisadores
• Processo FAPESP: 07/59017-9 - Avaliacao do potencial antimicrobiano dos principais constituintes das raizes de viguiera arenaria backer (asteraceae).
• Beneficiário: Thiago Sousa Porto
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica