Pimarane-type Diterpenes: Antimicrobial Activity against Oral Pathogens

Author(s):Show less -

Porto, Thiago S. ^[1] ; Rangel, Rander ^[1] ; Furtado, Niege A. J. C. ^[2] ; de Carvalho, Tatiane C. ^[1] ; Martins, Carlos H. G. ^[1] ; Veneziani, Rodrigo C. S. ^[1] ; Da Costa, Fernando B. ^[2] ; Vinholis, Adriana H. C. ^[1] ; Cunha, Wilson R. ^[1] ; Heleno, Vladimir C. G. ^[1] ; Ambrosio, Sergio R. ^[1]

Affiliation

^[1] Univ Franca, Nucleo Pesquisa Ciencias Exatas & Tecnol, Franca, SP - Brazil

^[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, BR-14049 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: Molecules; v. 14, n. 1, p. 191-199, JAN 2009.
• Web of Science Citations: 68

Abstract

Seven pimarane type-diterpenes re-isolated from Viguiera arenaria Baker and two semi-synthetic pimarane derivatives were evaluated in vitro against the following main microorganisms responsible for dental caries: Streptococcus salivarius, S. sobrinus, S. mutans, S. mitis, S. sanguinis and Lactobacillus casei. The compounds ent-pimara-8(14), 15-dien-19-oic acid (PA); ent-8(14), 15-pimaradien-3 beta-ol; ent-15-pimarene-8 beta, 19-diol; ent-8(14), 15-pimaradien-3 beta-acetoxy and the sodium salt derivative of PA were the most active compounds, displaying MIC values ranging from 2 to 8 mu g.mL(-1). Thus, this class of compounds seems promising as a class of new effective anticariogenic agents. Furthermore, our results also allow us to conclude that minor structural differences among these diterpenes significantly influence their antimicrobial activity, bringing new perspectives to the discovery of new natural compounds that could be employed in the development of oral care products. (AU)

• FAPESP's process: 07/54762-8 - Obtaining structural analogues of pimaradienoic acid through the process of fungal biotransformation and study of the effect of these metabolites on the activity of the TcDHODH enzyme and on the contraction of the vascular smooth muscle of the aorta artery of mice
• Grantee: Sergio Ricardo Ambrosio
• Support Opportunities: BIOTA-FAPESP Program - Young Investigators Grants