Photosensitizer-Loaded Magnetic Nanoemulsion for Use in Synergic Photodynamic and Magnetohyperthermia Therapies of Neoplastic Cells

Autor(es)

Primo, Fernando L. ^[1] ; Rodrigues, Marcilene M. A. ^[2] ; Simioni, Andreza Ribeiro ^[2] ; Lacava, Zulmira G. M. ^[3] ; Morais, Paulo C. ^[4] ; Tedesco, Antonio C. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Pret, Lab Fotobiol & Fotomed, Dept Quim, BR-14040901 Ribeirao Preto, SP - Brazil

^[3] Univ Brasilia, Inst Ciencias Biol, Dept Genet & Morfol, BR-70910900 Brasilia, DF - Brazil

^[4] Univ Brasilia, Inst Fis, BR-70910900 Brasilia, DF - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Nanoscience and Nanotechnology; v. 8, n. 11, p. 5873-5877, NOV 2008.
• Citações Web of Science: 29

Resumo

In this study a magnetic nanoemulsion (MNE) was developed from a mixture of two components, namely biodegradable surfactants and biocompatible citrate-coated cobalt ferrite-based magnetic fluid, for entrapment of Zn(II)-Phthalocyanine (ZnPc), the latter a classical photosensitizer (PS) species used in photodynamic therapy (PDT) procedures. The sample's stability was evaluated as a function of time using photocorrelation spectroscopy (PCS) for determination of the average hydrodynamic diameter, diameter dispersion and zeta potential. The ZnPc-loaded magneto nanoemulstion (ZnPc/MNE) formulation was evaluated in vitro assays to access the phototoxicity and the effect of application of AC magnetic fields (magnetohyperthermia damage) after incubation with J774-A1 macrophages cells. Darkness toxicity, phototoxicity and AC magnetic field exposures revealed an enhancement response for combined photodynamic and magnetohyperthermia (MHT) processes, indicating the presence of the synergic effect. (AU)

• Processo FAPESP: 04/00860-0 - Estudos de silício-naftalo ftalocianina como agente potencialmente ativo na terapia fotodinâmica de neoplasias cutâneas e sistêmicas
• Beneficiário: Andreza Ribeiro Simioni
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 06/50562-1 - Avaliacao do uso de laser de baixa potencia e agentes fotossensibilizadores associados a sistemas de liberacao nanoestruturados no tratamento de feridas e/ou outras doencas cutaneas
• Beneficiário: Fernando Lucas Primo
• Modalidade de apoio: Bolsas no Brasil - Doutorado