| Full text | |
| Author(s): |
Primo, Fernando L.
[1]
;
Rodrigues, Marcilene M. A.
[2]
;
Simioni, Andreza Ribeiro
[2]
;
Lacava, Zulmira G. M.
[3]
;
Morais, Paulo C.
[4]
;
Tedesco, Antonio C.
[2]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Pret, Lab Fotobiol & Fotomed, Dept Quim, BR-14040901 Ribeirao Preto, SP - Brazil
[3] Univ Brasilia, Inst Ciencias Biol, Dept Genet & Morfol, BR-70910900 Brasilia, DF - Brazil
[4] Univ Brasilia, Inst Fis, BR-70910900 Brasilia, DF - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Journal of Nanoscience and Nanotechnology; v. 8, n. 11, p. 5873-5877, NOV 2008. |
| Web of Science Citations: | 29 |
| Abstract | |
In this study a magnetic nanoemulsion (MNE) was developed from a mixture of two components, namely biodegradable surfactants and biocompatible citrate-coated cobalt ferrite-based magnetic fluid, for entrapment of Zn(II)-Phthalocyanine (ZnPc), the latter a classical photosensitizer (PS) species used in photodynamic therapy (PDT) procedures. The sample's stability was evaluated as a function of time using photocorrelation spectroscopy (PCS) for determination of the average hydrodynamic diameter, diameter dispersion and zeta potential. The ZnPc-loaded magneto nanoemulstion (ZnPc/MNE) formulation was evaluated in vitro assays to access the phototoxicity and the effect of application of AC magnetic fields (magnetohyperthermia damage) after incubation with J774-A1 macrophages cells. Darkness toxicity, phototoxicity and AC magnetic field exposures revealed an enhancement response for combined photodynamic and magnetohyperthermia (MHT) processes, indicating the presence of the synergic effect. (AU) | |