Testicular Sertoli cell function in male systemic lupus erythematosus

Autor(es)

Suehiro, R. M. ^[1] ; Borba, E. F. ^[1] ; Bonfa, E. ^[1] ; Okay, T. S. ^[2] ; Cocuzza, M. ^[3] ; Soares, P. M. F. ^[1] ; Silva, C. A. A. ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Div Rheumatol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Pediat Lab, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Div Urol, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Fac Med, Pediat Rheumatol Unit, Dept Pediat, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: RHEUMATOLOGY; v. 47, n. 11, p. 1692-1697, NOV 2008.
• Citações Web of Science: 34

Resumo

Objective. To assess the testicular Sertoli cell function in male SLE patients. Methods. Thirty-four consecutive patients were prospectively selected to evaluate serum inhibin B. Clinical features, treatment, semen analysis, urological evaluation, testicular ultrasound, hormones and anti-sperm antibodies were determined. Results. Patients were subdivided into two groups: low serum inhibin B (Group 1, n = 8) and normal levels (Group 2, n 26). The median sperm concentration (P = 0.024), total sperm count (P = 0.023) and total motile sperm count (P = 0.025) were lower in Group 1. Inhibin B levels were positively correlated with sperm concentration (r = 0.343), total motile sperm count (r = 0.357), and negatively correlated with follicule-stimulating hormone (FSH) (r = 0.699) and luteinizing hormone (r = 0.397). The median serum inhibin B was lower in SLE patients treated with intravenous cyclophosphamide (IVCYC) compared with those without this therapy (P = 0.031). Further evaluation of the 26 SLE patients with normal inhibin B and FSH levels revealed that medians of inhibin B/FSH ratio were lower in SLE patients with oligozoospermia compared with normozoospermia (P = 0.004). This ratio was also lower in SLE patients treated with IVCYC than those without this therapy (P = 0.04). In contrast, inhibin B serum level alone did not discriminate the later group of patients (P = 0.12). Conclusions. This is the first study to identify a high frequency of testicular Sertoli cell dysfunction in male SLE associated with semen abnormalities. Further prospective studies are necessary to determine if inhibin levels and inhibin B/FSH ratio will be an earlier and useful marker of IVCYC toxicity in these patients. (AU)

• Processo FAPESP: 04/07832-2 - Avaliação da função gonadal em pacientes do sexo masculino com lúpus eritematoso sistêmico
• Beneficiário: Clovis Artur Almeida da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/52668-9 - Avaliação da função gonadal em pacientes do sexo masculino com lúpus eritematoso sistêmico
• Beneficiário: Aline Presto Braga
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico