Adverse effect of the anabolic-androgenic steroid mesterolone on cardiac remodelling and lipoprotein profile is attenuated by aerobicz exercise training

Autor(es)

Fontana, Karina ^{[1, 2]} ; Franco Oliveira, Helena Coutinho ^[3] ; Leonardo, Marta Beatriz ^[1] ; Mandarim-de-Lacerda, Carlos Alberto ^[4] ; da Cruz-Hoefling, Maria Alice ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Biol, Dept Histol & Embriol, BR-13083970 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Inst Biol, Fac Med Sci, Dept Pharmacol, BR-13083970 Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Inst Biol, Dept Physiol & Biophys, BR-13083970 Campinas, SP - Brazil

^[4] Univ Estado Rio De Janeiro, Inst Biol, Biomed Ctr, Lab Morphometry & Cardiovasc Morphol, Rio De Janeiro - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Experimental Pathology; v. 89, n. 5, p. 358-366, OCT 2008.
• Citações Web of Science: 19

Resumo

Abuse of anabolic-androgenic steroids (AAS) for improving physical performance is associated with serious, sometimes fatal, adverse effects. The aim of the present work was to investigate the effects of AAS on the cardiac structure and the plasma lipoprotein profile isolated and in combination with exercise. Transgenic mice with a human lipaemic phenotype (expressing cholesteryl ester transfer protein on the LDL receptor knockout background) were used in this study. Sedentary and exercised mice (treadmill running, five times per week for 6 weeks) were treated with mesterolone (2 mu g/g body weight) or vehicle (control-C) in the last 3 weeks. Four groups were compared: (i) exercise + mesterolone (Ex-M), (ii) exercise + vehicle (Ex-C), (iii) sedentary + mesterolone (Sed-M) and (iv) sedentary + vehicle (Sed-C). Arterial blood pressure and body mass increased in all groups along time, but Sed-M reached the highest values and Ex-C the lowest. Treatment with mesterolone increased total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-c) and very LDL-c (VLDL-c) plasma levels. However, exercise blunted some of these deleterious effects by increasing high-density lipoprotein cholesterol and decreasing LDL-c, VLDL-c and triglycerides. Exercise training induced beneficial effects, such as physiological cardiomyocyte hypertrophy, increase in myocardial circulation and decrease in cardiac interstitium. However, mesterolone impaired such physiological gains and in addition increased troponin T plasma levels both in sedentary and exercised mice. Thus, while mesterolone induced pro-atherogenic lipoprotein profile and pathogenic cardiac hypertrophy, exercise counteracted these effects and modified favourably both the lipoprotein profile and the cardiac remodelling induced by mesterolone. (AU)

• Processo FAPESP: 04/13767-9 - Influência dos esteroides anabólico-androgênicos (EAA) associados ao exercício físico sobre os músculos de camundongos que expressam proteína de transferência de éster de colesteril (CETP) com deficiência parcial do receptor de LDL-colesterol
• Beneficiário: Maria Alice da Cruz Hofling
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 04/13768-5 - Influência dos esteróides anabólico-androgênicos (EAA) associados ao exercício físico sobre os músculos de camundongos que expressam proteína de transferência de éster de colesteril (CETP) com deficiência parcial do receptor de LDL-colesterol
• Beneficiário: Karina Fontana
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto