In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi

Autor(es)

Lopes, Adriana Aparecida ^[1] ; Lopez, Silvia Noeli ^[1] ; Regasini, Luis Octavio ^[1] ; Batista Junior, Joao Marcos ^[1] ; Ambrosio, Daniela Luz ^[2] ; Kato, Massuo Jorge ^[3] ; Bolzani, Vanderlan da Silva ^[1] ; Barretto Cicarelli, Regina Maria ^[2] ; Furlan, Maysa ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP - Brazil

^[2] Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP - Brazil

^[3] Univ Sao Paulo, Inst Quim, BR-05599970 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NATURAL PRODUCT RESEARCH; v. 22, n. 12, p. 1040-1046, 2008.
• Citações Web of Science: 24

Resumo

This study describes the antichagasic potential of five compounds isolated from leaves of Piper crassinervium (Piperaceae). Two prenylated benzoic acid derivatives, one prenylated hydroquinone and two flavanones, were evaluated. The in vitro trypanocidal activity was determined against epimastigote forms of Trypanosoma cruzi (Y strain), the etiologic agent of Chagas disease. The most active compound was the prenylated hydroquinone {[}1,4-dihydroxy-2-(3(0),7(0)-dimethyl-1(0)-oxo-2(0)-E,6(0)-octadienyl)b enzene] with an IC(50) value of 6.10 g mL(-1), which was in the same order of activity if compared with the positive control benznidazole (IC(50) = 1.60 mu g mL(-1)). This is the first report of trypanocidal activity for prenylated hydroquinone and benzoic acid derivatives. (AU)

• Processo FAPESP: 03/11524-9 - Biossíntese em espécies de Celastraceae, Hippocrateaceae e Piperaceae: análise do metaboloma - proteoma de metabólitos secundários com potencial biológico
• Beneficiário: Maysa Furlan
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/57042-0 - Origem biossintética e aspectos evolutivos de metabólitos secundários de angiopermas basais
• Beneficiário: Massuo Jorge Kato
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 06/50086-5 - Caracterização da preniltransferase de Piper crassinervium e gaudichaudianum (Piperaceae)
• Beneficiário: Silvia Noelí López
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 03/01867-6 - Estudo biossintético, proteômico e genômico das preniltransferases em Piper gaudichaudianum e Piper crassinervium (Piperaceae)
• Beneficiário: Adriana Aparecida Lopes
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto