In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi

Author(s)

Lopes, Adriana Aparecida ^[1] ; Lopez, Silvia Noeli ^[1] ; Regasini, Luis Octavio ^[1] ; Batista Junior, Joao Marcos ^[1] ; Ambrosio, Daniela Luz ^[2] ; Kato, Massuo Jorge ^[3] ; Bolzani, Vanderlan da Silva ^[1] ; Barretto Cicarelli, Regina Maria ^[2] ; Furlan, Maysa ^[1]

Affiliation

^[1] Univ Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP - Brazil

^[2] Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP - Brazil

^[3] Univ Sao Paulo, Inst Quim, BR-05599970 Sao Paulo - Brazil

• Document type: Journal article
• Source: NATURAL PRODUCT RESEARCH; v. 22, n. 12, p. 1040-1046, 2008.
• Web of Science Citations: 24

Abstract

This study describes the antichagasic potential of five compounds isolated from leaves of Piper crassinervium (Piperaceae). Two prenylated benzoic acid derivatives, one prenylated hydroquinone and two flavanones, were evaluated. The in vitro trypanocidal activity was determined against epimastigote forms of Trypanosoma cruzi (Y strain), the etiologic agent of Chagas disease. The most active compound was the prenylated hydroquinone {[}1,4-dihydroxy-2-(3(0),7(0)-dimethyl-1(0)-oxo-2(0)-E,6(0)-octadienyl)b enzene] with an IC(50) value of 6.10 g mL(-1), which was in the same order of activity if compared with the positive control benznidazole (IC(50) = 1.60 mu g mL(-1)). This is the first report of trypanocidal activity for prenylated hydroquinone and benzoic acid derivatives. (AU)

• FAPESP's process: 06/50086-5 - Characterization of prenyltransferase of Piper crassinervium and gaudichaudianum (Piperaceae)
• Grantee: Silvia Noelí López
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 03/01867-6 - Biosynthetic, proteomic and genomic study of the prenyltransferases Piper gaudichaudianum and Piper crassinervium (Piperaceae)
• Grantee: Adriana Aparecida Lopes
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)