| Texto completo | |
| Autor(es): |
Oliveira, H. C.
[1]
;
Popi, A. F.
[1, 2]
;
Bachi, A. L. L.
[1]
;
Nonogaki, S.
[3]
;
Lopes, J. D.
[1]
;
Mariano, M.
[1, 2]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo, Discipline Immunol, Dept Microbiol Immunol & Parasitol, BR-04023900 Sao Paulo - Brazil
[2] Univ Paulista, Lab Biol Mol & Celular, Paulista - Brazil
[3] Hosp Canc, Fundacao Antonio Prudente, Sao Paulo - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Immunobiology; v. 215, n. 3, p. 215-222, MAR 2010. |
| Citações Web of Science: | 22 |
| Resumo | |
Wound healing is a complex phenomenon whose mechanisms are not fully understood. Although inflammatory cells are recruited to the site of the lesion there are no reports concerning the participation of B lymphocytes in tissue repair. As demonstrated in our laboratory, B-1 cells migrate to a non-specific inflammatory focus and differentiate into a phagocyte. It has been reported that BALB/Xid mice are deficient in B-1 cells. Using this model, here we report that BALB/Xid mice have an increased inflammatory response, a delayed wound-healing process, a prominent neutrophilic infiltration of the lesion, and an increased neovascularization of the lesion as compared with BALB/c and BALB/Xid reconstituted with B-1 cells. The infiltration of B-1 cells into the wound was demonstrated. As B-1 cells secret and use interleukin 10 (IL-10) as an autocrine growth factor, the possible participation of this interleukin in the kinetics of wound healing was investigated. Results show that C57/BL6 IL-10 KO mice had an increased inflammatory response when compared with C57/BL6 and C57/BL6 IL-10 KO mice reconstituted with B-1 cells, thus suggesting that the observed effects of B-1 cells in the healing process is mediated by this interleukin. However, the mechanisms by which IL-10 influence these phenomena remain to be uncovered. (C) 2009 Elsevier GmbH. All rights reserved. (AU) | |
| Processo FAPESP: | 04/08506-1 - Células B-1: origem, diferenciação e participação na inflamação, cicatrização e rejeição de enxerto |
| Beneficiário: | Mario Mariano |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |