Human cytomegalovirus reinfection is associated with intrauterine transmission in a highly cytomegalovirus-immune maternal population

Autor(es)

Yamamoto, Aparecida Yulie ^[1] ; Mussi-Pinhata, Marisa Marcia ^[1] ; Boppana, Suresh B. ^{[2, 3]} ; Novak, Zdenek ^[2] ; Wagatsuma, Virginia M. ^[1] ; Oliveira, Patricia de Frizzo ^[1] ; Duarte, Geraldo ^[4] ; Britt, William J. ^{[2, 3, 5]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pediat, Sao Paulo - Brazil

^[2] Univ Alabama, Sch Med, Dept Pediat, Birmingham, AL - USA

^[3] Univ Alabama, Sch Med, Dept Microbiol, Birmingham, AL 35294 - USA

^[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Gynecol & Obstet, Sao Paulo - Brazil

^[5] Univ Alabama, Sch Med, Dept Neurobiol, Birmingham, AL 35294 - USA

• Tipo de documento: Artigo Científico
• Fonte: American Journal of Obstetrics and Gynecology; v. 202, n. 3 MAR 2010.
• Citações Web of Science: 88

Resumo

OBJECTIVE: To determine contribution of reinfection with new strains of cytomegalovirus in cytomegalovirus seromimmune women to incidence of congenital cytomegalovirus infection. STUDY DESIGN: In 7848 women studied prospectively for congenital cytomegalovirus infection from a population with near universal cytomegalovirus seroimmunity, sera from 40 mothers of congenitally infected infants and 109 mothers of uninfected newborns were analyzed for strain-specific anticytomegalovirus antibodies. RESULTS: All women were cytomegalovirus seroimmune at first prenatal visit. Reactivity for 2 cytomegalovirus strains was found in 14 of 40 study mothers and in 17 of 109 control mothers at first prenatal visit (P=.009). Seven of 40 (17.5%) study women and 5 of 109 (4.6%) controls (P=.002) acquired antibodies reactive with new cytomegalovirus strains during pregnancy. Evidence of infection with more than 1 strain of cytomegalovirus before or during current pregnancy occurred in 21 of 40 study mothers and 22 of 109 controls (P<.0001). CONCLUSION: Maternal reinfection by new strains of cytomegalovirus is a major source of congenital infection in this population. (AU)

• Processo FAPESP: 02/04166-6 - Infecção congênita por citomegalovírus em população com elevada soropositividade: caracterização molecular das cepas virais e avaliação da ocorrência de reinfecção materna
• Beneficiário: Aparecida Yulie Yamamoto
• Modalidade de apoio: Auxílio à Pesquisa - Regular