Classification of individuals with dyslipidaemia controlled by statins according to plasma biomarkers of oxidative stress using cluster analysis

Autor(es)

Botelho, Patricia B. ^[1] ; Fioratti, Cyntia O. ^[1] ; Abdalla, Dulcineia S. P. ^[2] ; Bertolami, Marcelo C. ^[3] ; Castro, Inar A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Food & Expt Nutr, Fac Pharmaceut Sci, BR-05508900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Clin & Toxicol Anal, Fac Pharmaceut Sci, BR-05508900 Sao Paulo - Brazil

^[3] Dante Pazzanese Inst Cardiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BRITISH JOURNAL OF NUTRITION; v. 103, n. 2, p. 256-265, JAN 28 2010.
• Citações Web of Science: 8

Resumo

Oxidative stress is a physiological condition that is associated with atherosclerosis. and it can be influenced by diet. Our objective was to group fifty-seven individuals with dyslipidaemia controlled by statins according to four oxidative biomarkers, and to evaluate the diet pattern and blood biochemistry differences between these groups. Blood samples were collected and the following parameters were evaluated: diet intake; plasma fatty acids; lipoprotein concentration; glucose; oxidised LDL (oxLDL); malondialdehyde (MDA): total antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing ability power assays. Individuals were separated into five groups by cluster analysis. All groups showed a difference with respect to at least one of the four oxidative stress biomarkers. The separation of individuals in the first axis was based upon their total antioxidant activity. Clusters located on the right side showed higher total antioxidant activity, higher myristic fatty acid and lower arachidonic fatty acid proportions than clusters located on the left side. A negative correlation was observed between DPPH and the peroxidability index. The second axis showed differences in oxidation status as measured by MDA and oxLDL concentrations. Clusters located on the Upper side showed higher oxidative status and lower HDL cholesterol concentration than clusters located on the lower side. There were no differences in diet among the five clusters. Therefore, fatty acid synthesis and HDL cholesterol concentration seem to exert a more significant effect on the oxidative conditions of the individuals with dyslipidaemia controlled by statins than does their food intake. (AU)

• Processo FAPESP: 07/01476-8 - Efeito da dieta na variacao de biomarcadores do stress oxidativo em individuos com dislipidemia.
• Beneficiário: Patrícia Borges Botelho Gamba
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 08/10826-5 - Aplicação de técnicas estatísticas multivariadas na avaliação de associações entre biomarcadores do stress oxidativo e fatores dietéticos em indivíduos com dislipidemia
• Beneficiário: Cyntia Okoshi Fioratti
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 08/00482-7 - Aplicação de técnicas estatísticas multivariadas na avaliação de associações entre biomarcadores do stress oxidativo e fatores dietéticos em indivíduos com dislipidemia
• Beneficiário: Inar Castro Erger
• Modalidade de apoio: Auxílio à Pesquisa - Regular