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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Classification of individuals with dyslipidaemia controlled by statins according to plasma biomarkers of oxidative stress using cluster analysis

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Author(s):
Botelho, Patricia B. [1] ; Fioratti, Cyntia O. [1] ; Abdalla, Dulcineia S. P. [2] ; Bertolami, Marcelo C. [3] ; Castro, Inar A. [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Dept Food & Expt Nutr, Fac Pharmaceut Sci, BR-05508900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Clin & Toxicol Anal, Fac Pharmaceut Sci, BR-05508900 Sao Paulo - Brazil
[3] Dante Pazzanese Inst Cardiol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: BRITISH JOURNAL OF NUTRITION; v. 103, n. 2, p. 256-265, JAN 28 2010.
Web of Science Citations: 8
Abstract

Oxidative stress is a physiological condition that is associated with atherosclerosis. and it can be influenced by diet. Our objective was to group fifty-seven individuals with dyslipidaemia controlled by statins according to four oxidative biomarkers, and to evaluate the diet pattern and blood biochemistry differences between these groups. Blood samples were collected and the following parameters were evaluated: diet intake; plasma fatty acids; lipoprotein concentration; glucose; oxidised LDL (oxLDL); malondialdehyde (MDA): total antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing ability power assays. Individuals were separated into five groups by cluster analysis. All groups showed a difference with respect to at least one of the four oxidative stress biomarkers. The separation of individuals in the first axis was based upon their total antioxidant activity. Clusters located on the right side showed higher total antioxidant activity, higher myristic fatty acid and lower arachidonic fatty acid proportions than clusters located on the left side. A negative correlation was observed between DPPH and the peroxidability index. The second axis showed differences in oxidation status as measured by MDA and oxLDL concentrations. Clusters located on the Upper side showed higher oxidative status and lower HDL cholesterol concentration than clusters located on the lower side. There were no differences in diet among the five clusters. Therefore, fatty acid synthesis and HDL cholesterol concentration seem to exert a more significant effect on the oxidative conditions of the individuals with dyslipidaemia controlled by statins than does their food intake. (AU)

FAPESP's process: 08/10826-5 - Application of multivariate statistical techniques to evaluate the association between biomarkers of the oxidative stress and dietetic factors in dislipidemic individuals
Grantee:Cyntia Okoshi Fioratti
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 08/00482-7 - Application of multivariate statistical techniques to evaluate the association between biomarkers of the oxidative stress and dietetic factors in dislipidemic individuals
Grantee:Inar Castro Erger
Support Opportunities: Regular Research Grants