Relationship between Optical Coherence Tomography, Pattern Electroretinogram and Automated Perimetry in Eyes with Temporal Hemianopia from Chiasmal Compression

Autor(es)

Monteiro, Mario L. R. ^[1] ; Cunha, Leonardo P. ^[1] ; Costa-Cunha, Luciana V. F. ^[1] ; Maia, Jr., Otacilio O. ^[1] ; Oyamada, Maria K. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Hosp Clin, Div Ophthalmol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE; v. 50, n. 8, p. 3535-3541, AUG 2009.
• Citações Web of Science: 36

Resumo

PURPOSE. To evaluate the relationship between pattern electroretinogram (PERG) amplitude, macular and retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (OCT), and visual field (VF) loss on standard automated perimetry (SAP) in eyes with temporal hemianopia from chiasmal compression. METHODS. Forty-one eyes from 41 patients with permanent temporal VF defects from chiasmal compression and 41 healthy subjects underwent transient full-field and hemifield (temporal or nasal) stimulation PERG, SAP and time domain-OCT macular and RNFL thickness measurements. Comparisons were made using Student's t-test. Deviation from normal VF sensitivity for the central 18 of VF was expressed in 1/Lambert units. Correlations between measurements were verified by linear regression analysis. RESULTS. PERG and OCT measurements were significantly lower in eyes with temporal hemianopia than in normal eyes. A significant correlation was found between VF sensitivity loss and fullfield or nasal, but not temporal, hemifield PERG amplitude. Likewise a significant correlation was found between VF sensitivity loss and most OCT parameters. No significant correlation was observed between OCT and PERG parameters, except for nasal hemifield amplitude. A significant correlation was observed between several macular and RNFL thickness parameters. CONCLUSIONS. In patients with chiasmal compression, PERG amplitude and OCT thickness measurements were significant related to VF loss, but not to each other. OCT and PERG quantify neuronal loss differently, but both technologies are useful in understanding structure-function relationship in patients with chiasmal compression. (ClinicalTrials.gov number, NCT00553761.) (Invest Ophthalmol Vis Sci. 2009; 50: 3535-3541) DOI:10.1167/iovs.08-3093 (AU)

• Processo FAPESP: 06/61549-6 - Comparação entre a tomografia de coerência óptica e o eletrorretinograma de padrão reverso (de campo total e multifocal) na detecção de perda neural na atrofia em banda do nervo óptico
• Beneficiário: Mário Luiz Ribeiro Monteiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/54142-0 - Comparação entre a tomografia de coerência óptica e o eletrorretinograma de padrão reverso (de campo total e multifocal) na detecção da perda neural na atrofia em banda do nervo óptico
• Beneficiário: Leonardo Provetti Cunha
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto