| Texto completo | |
| Autor(es): |
Oliveira, Lucinei Roberto
[1]
;
Ribeiro-Silva, Alfredo
[1]
;
Oliveira Costa, Joao Paulo
[1]
;
Simoes, Aguinaldo Luiz
[2]
;
Sala Di Matteo, Miguel Angel
[3]
;
Zucoloto, Sergio
[1]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Dept Pathol, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Dept Genet, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Fac Dent Ribeirao Preto, Ribeirao Preto Med Sch, Dept Morphol Stomatol & Physiol, BR-14049900 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology; v. 106, n. 5, p. 685-695, 2008. |
| Citações Web of Science: | 30 |
| Resumo | |
Objectives. The aims of this report were to describe the 5-year overall survival (OS) in a group of oral squamous cell carcinoma (OSCC) patients and to investigate the effects of age, gender, anatomic localization, tumor evolution time, smoking and alcohol intake, nodal status, tumoral recurrences, histologic classification, p53 and p63 immunoexpression, human papillomavirus DNA presence, and treatment on the prognostic outcome. Study design. Survival curves were generated using Kaplan-Meier method, and univariate and multivariate analyses were made using the log rank test and Cox regression, respectively. Results. The 5-year OS was 28.6%, and the univariate analysis showed significant results for p53 and p63 immunoexpression, age, and anatomic localization. The Cox regression demonstrated poor OS for tumors with p53 immunoexpression and for patients aged over 60 years. There were also significant differences in survival depending on the anatomic localizations. Conclusion. These results highlight the influence of p53 immunoexpression, age, and anatomic localization in OSCC evolution. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 106: 685-95) (AU) | |
| Processo FAPESP: | 03/02532-8 - Fatores reguladores da proliferação celular, angiogênese e diferenciação celular em carcinomas mamários |
| Beneficiário: | Sérgio Zucoloto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |