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(Reference retrieved automatically from Google Scholar through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prognostic factors and survival analysis in a sample of oral squamous cell carcinoma patients

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Author(s):
Oliveira, Lucinei Roberto [1] ; Ribeiro-Silva, Alfredo [1] ; Oliveira Costa, Joao Paulo [1] ; Simoes, Aguinaldo Luiz [2] ; Sala Di Matteo, Miguel Angel [3] ; Zucoloto, Sergio [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Dept Pathol, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Dept Genet, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Fac Dent Ribeirao Preto, Ribeirao Preto Med Sch, Dept Morphol Stomatol & Physiol, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology; v. 106, n. 5, p. 685-695, 2008.
Web of Science Citations: 30
Abstract

Objectives. The aims of this report were to describe the 5-year overall survival (OS) in a group of oral squamous cell carcinoma (OSCC) patients and to investigate the effects of age, gender, anatomic localization, tumor evolution time, smoking and alcohol intake, nodal status, tumoral recurrences, histologic classification, p53 and p63 immunoexpression, human papillomavirus DNA presence, and treatment on the prognostic outcome. Study design. Survival curves were generated using Kaplan-Meier method, and univariate and multivariate analyses were made using the log rank test and Cox regression, respectively. Results. The 5-year OS was 28.6%, and the univariate analysis showed significant results for p53 and p63 immunoexpression, age, and anatomic localization. The Cox regression demonstrated poor OS for tumors with p53 immunoexpression and for patients aged over 60 years. There were also significant differences in survival depending on the anatomic localizations. Conclusion. These results highlight the influence of p53 immunoexpression, age, and anatomic localization in OSCC evolution. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 106: 685-95) (AU)