Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: role in functional capacity and mortality

Autor(es):Mostrar menos -

Jorge, Luciana ^[1] ; Rodrigues, Bruno ^[1] ; Rosa, Kaleizu Teodoro ^[1] ; Malfitano, Christiane ^[1] ; Alba Loureiro, Tatiana Carolina ^[2] ; Medeiros, Alessandra ^[3] ; Curi, Rui ^[2] ; Brum, Patricia Chakur ^[3] ; Lacchini, Silvia ^[4] ; Montano, Nicola ^[5] ; De Angelis, Katia ^[6] ; Irigoyen, Maria-Claudia ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Heart Inst InCor, Hypertens Unit, BR-05403000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05403000 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Phys Educ & Sports, BR-05403000 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, BR-05403000 Sao Paulo - Brazil

^[5] Univ Milan, Luigi Sacco Hosp, Dept Clin Sci, Milan - Italy

^[6] Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN HEART JOURNAL; v. 32, n. 7, p. 904-912, 2011.
• Citações Web of Science: 34

Resumo

Aims To test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen consumption (VO2 max), and mortality after myocardial infarction (MI) in rats. Methods and results Male Wistar rats were divided into: control (C), sedentary-infarcted (SI), and trained-infarcted (TI). One week after MI, TI group underwent an ET protocol (90 days, 50-70% VO2 max). Left ventricular function was evaluated noninvasively and invasively. Baroreflex sensitivity, heart rate variability, and pulse interval were measured. Cardiac output (CO) and regional BFs were determined using coloured microspheres. Infarcted area was reduced in TI (19 +/- 6%) compared with SI (34 +/- 5%) after ET. Exercise training improved the LV and autonomic functions, the CO and regional BF changes induced by MI, as well as increased SERCA2 expression and mRNA vascular endothelial growth factor levels. These changes brought about by ET resulted in mortality rate reduction in the TI (13%) group compared with the SI (54%) group. Conclusion Early aerobic ET reduced cardiac and peripheral dysfunctions and preserved cardiovascular autonomic control after MI in trained rats. Consequently, these ET-induced changes resulted in improved functional capacity and survival after MI. (AU)

• Processo FAPESP: 06/53800-0 - Papel do treinamento fisico na mortalidade de ratos diabeticos pos infarto do miocardio: avaliacoes das funcoes cardiacas.
• Beneficiário: Luciana Jorge
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 01/00009-0 - Estudo integrado da hipertensão arterial: caracterização molecular e funcional do sistema cardiovascular
• Beneficiário: Eduardo Moacyr Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 07/57595-5 - Efeitos do treinamento físico no controle autônomo cardiovascular em fêmeas saudáveis e submetidas à privação dos hormônios ovarianos: papel do estresse oxidativo
• Beneficiário: Kátia de Angelis Lobo D Avila
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores