Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: role in functional capacity and mortality

Author(s):Show less -

Jorge, Luciana ^[1] ; Rodrigues, Bruno ^[1] ; Rosa, Kaleizu Teodoro ^[1] ; Malfitano, Christiane ^[1] ; Alba Loureiro, Tatiana Carolina ^[2] ; Medeiros, Alessandra ^[3] ; Curi, Rui ^[2] ; Brum, Patricia Chakur ^[3] ; Lacchini, Silvia ^[4] ; Montano, Nicola ^[5] ; De Angelis, Katia ^[6] ; Irigoyen, Maria-Claudia ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Med, Heart Inst InCor, Hypertens Unit, BR-05403000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05403000 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Phys Educ & Sports, BR-05403000 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, BR-05403000 Sao Paulo - Brazil

^[5] Univ Milan, Luigi Sacco Hosp, Dept Clin Sci, Milan - Italy

^[6] Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo - Brazil

• Document type: Journal article
• Source: EUROPEAN HEART JOURNAL; v. 32, n. 7, p. 904-912, 2011.
• Web of Science Citations: 34

Abstract

Aims To test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen consumption (VO2 max), and mortality after myocardial infarction (MI) in rats. Methods and results Male Wistar rats were divided into: control (C), sedentary-infarcted (SI), and trained-infarcted (TI). One week after MI, TI group underwent an ET protocol (90 days, 50-70% VO2 max). Left ventricular function was evaluated noninvasively and invasively. Baroreflex sensitivity, heart rate variability, and pulse interval were measured. Cardiac output (CO) and regional BFs were determined using coloured microspheres. Infarcted area was reduced in TI (19 +/- 6%) compared with SI (34 +/- 5%) after ET. Exercise training improved the LV and autonomic functions, the CO and regional BF changes induced by MI, as well as increased SERCA2 expression and mRNA vascular endothelial growth factor levels. These changes brought about by ET resulted in mortality rate reduction in the TI (13%) group compared with the SI (54%) group. Conclusion Early aerobic ET reduced cardiac and peripheral dysfunctions and preserved cardiovascular autonomic control after MI in trained rats. Consequently, these ET-induced changes resulted in improved functional capacity and survival after MI. (AU)

• FAPESP's process: 01/00009-0 - An integrated approach for the dissection of primary hypertension: molecular and functional characterization of the cardiovascular system
• Grantee: Eduardo Moacyr Krieger
• Support Opportunities: Research Projects - Thematic Grants