Advanced search
Start date
Betweenand

Effects of exercise training and cholinergic stimulation with pyridostigmine bromide before and after myocardial infarction: role on cardiac and autonomic function, and inflammatory profile

Grant number: 13/14788-9
Support type:Regular Research Grants
Duration: December 01, 2013 - November 30, 2015
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Bruno Rodrigues
Grantee:Bruno Rodrigues
Home Institution: Faculdade de Educação Física (FEF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Assoc. researchers:Maria Claudia Costa Irigoyen

Abstract

The autonomic nervous system derangement has been associated with an increased inflammatory status and together with changes in ventricular function results in high mortality rates in patients after myocardial infarction (MI). Cardiovascular, immune and autonomic exercise training (ET) benefits have led many researchers to suggest the ET as an important nonpharmacologic tool in the treatment and prevention of MI. On the other hand, the administration of pyridostigmine bromide (PYR), a drug that inhibits acetylcholinesterase action, has demonstrated positive effects on autonomic function in healthy subjects and coronary patients (in response to exercise). However, associations between these therapeutic strategies, ET and PYR, in the prevention and treatment of cardiac and autonomic changes, and inflammatory profile triggered by MI have been little studied and deserve attention. Thus, the aim of this study is to investigate the effects of ET (aerobic and resistance) associated with administration of PYR, previously and after MI, on cardiac abnormalities, and autonomic dysfunction in rats. Furthermore, the impact of these interventions on systemic and tissue inflammatory responses of infarcted rats will be verified. Guided by 3 subprojects, the realization of this study may have a significant clinical impact, clarifying mechanisms for preventing and / or mitigating the adverse effects of an ischemic event. (AU)

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BARBOZA, C. A.; FUKUSHIMA, A. R.; CARROZZI, N.; MACHI, J. F.; DOURADO, P. M. M.; MOSTARDA, C. T.; IRIGOYEN, M. C.; NATHANSON, L.; MORRIS, M.; CAPERUTO, E. C.; RODRIGUES, B. Cholinergic Stimulation by Pyridostigmine Bromide Before Myocardial Infarction Prevent Cardiac and Autonomic Dysfunction. SCIENTIFIC REPORTS, v. 9, FEB 21 2019. Web of Science Citations: 0.
FERIANI, DANIELE J.; COELHO-JUNIOR, HELIO J.; DE OLIVEIRA, JULIANA C. M. F.; DELBIN, MARIA A.; MOSTARDA, CRISTIANO T.; DOURADO, PAULO M. M.; CAPERUTO, ERICO C.; IRIGOYEN, MARIA C. C.; RODRIGUES, BRUNO. Pyridostigmine Improves the Effects of Resistance Exercise Training after Myocardial Infarction in Rats. FRONTIERS IN PHYSIOLOGY, v. 9, FEB 12 2018. Web of Science Citations: 4.
Protective Effects of Accumulated Aerobic Exercise in Infarcted Old Rats. International Journal of Cardiovascular Sciences, n. ahead, p. -, 2018.
DANIELE JARDIM FERIANI; HÉLIO JOSÉ COELHO-JÚNIOR; MARIA CLÁUDIA IRIGOYEN; BRUNO RODRIGUES. Protective Effects of Accumulated Aerobic Exercise in Infarcted Old Rats. International Journal of Cardiovascular Sciences, v. 31, n. 5, p. -, Out. 2018.
BARBOZA, C. A.; SOUZA, G. I. H.; OLIVEIRA, J. C. M. F.; SILVA, L. M.; MOSTARDA, C. T.; DOURADO, P. M. M.; OYAMA, L. M.; LIRA, F. S.; IRIGOYEN, M. C.; RODRIGUES, B. Cardioprotective Properties of Aerobic and Resistance Training Against Myocardial Infarction. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 37, n. 6, p. 421-430, JUN 2016. Web of Science Citations: 5.
RODRIGUES, FERNANDO; FERIANI, DANIELE JARDIM; BARBOZA, CATARINA ANDRADE; VERGILINO ABSSAMRA, MARCOS ELIAS; ROCHA, LEANDRO YANASE; CARROZI, NICOLLE MARTINS; MOSTARDA, CRISTIANO; FIGUEROA, DIEGO; HONORATO SOUZA, GABRIEL INACIO; DE ANGELIS, KATIA; IRIGOYEN, MARIA CLAUDIA; RODRIGUES, BRUNO. Cardioprotection afforded by exercise training prior to myocardial infarction is associated with autonomic function improvement. BMC CARDIOVASCULAR DISORDERS, v. 14, JUL 14 2014. Web of Science Citations: 10.
RODRIGUES, BRUNO; LIRA, FABIO S.; CONSOLIM-COLOMBO, FERNANDA M.; ROCHA, JURACI A.; CAPERUTO, ERICO C.; DE ANGELIS, KATIA; IRIGOYEN, MARIA-CLAUDIA. Role of Exercise Training on Autonomic Changes and Inflammatory Profile Induced by Myocardial Infarction. Mediators of Inflammation, 2014. Web of Science Citations: 11.
RODRIGUES, BRUNO; SANTANA, ALINE ALVES; SANTAMARINA, ALINE BOVETO; OYAMA, LILA MISSAE; CAPERUTO, ERICO CHAGAS; DE SOUZA, CLAUDIO TEODORO; BARBOZA, CATARINA DE ANDRADE; ROCHA, LEANDRO YANASE; FIGUEROA, DIEGO; MOSTARDA, CRISTIANO; IRIGOYEN, MARIA CLAUDIA; LIRA, FABIO SANTOS. Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System. Mediators of Inflammation, 2014. Web of Science Citations: 10.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
Distribution map of accesses to this page
Click here to view the access summary to this page.