Cardiac and autonomic adaptations to aerobic and resistance exercise training associated with cholinergic stimulation by pyridostigmine bromide in infarcted rats

• Grant number: 14/03908-6
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): October 01, 2014
• Effective date (End): February 29, 2016
• Field of knowledge: Health Sciences - Physical Education
• Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Érico Chagas Caperuto
• Grantee: Daniele Jardim Feriani
• Host Institution: Faculdade de Ciências Biológicas e da Saúde. Universidade São Judas Tadeu (USJT). São Paulo , SP, Brazil

Abstract

Due to its cardiovascular, metabolic and autonomic benefit, many researchers have suggested the Aerobic Exercise Training (AT) as an important non-pharmacological tool in the management of Myocardial Infarction (MI). Despite Resistance Training (RT) is considered an adjuvant in cardiac rehabilitation programs, evidence about its benefits are still scarce. On the other hand, the administration of pyridostigmine bromide (PYR), an inhibitor of acetylcholinesterase, has shown positive effects on autonomic function in healthy subjects and in coronary patients (in response to exercise). However, associations between these strategies, AT, RT and PYR on the treatment of cardiac, autonomic and functional changes triggered by IM have been understudied and deserve attention. Thus, the aim of this study is to evaluate the effects of AT or RT, associated or not with PYR treatment, on ventricular, hemodynamic and autonomic responses to MI in rats. MI animals will be subjected to 3 months of AT and RT alone or combined with PYR treatment. At the end of the protocols, ventricular, hemodynamic and autonomic evaluations will be conducted. Results will be presented as mean ± standard error of the mean, and statistical ANOVA tests will be properly applied. Values of P<0.05 will be considered significant. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERIANI, DANIELE J.; COELHO-JUNIOR, HELIO J.; DE OLIVEIRA, JULIANA C. M. F.; DELBIN, MARIA A.; MOSTARDA, CRISTIANO T.; DOURADO, PAULO M. M.; CAPERUTO, ERICO C.; IRIGOYEN, MARIA C. C.; RODRIGUES, BRUNO. Pyridostigmine Improves the Effects of Resistance Exercise Training after Myocardial Infarction in Rats. FRONTIERS IN PHYSIOLOGY, v. 9, FEB 12 2018. (14/19086-5, 13/14788-9, 14/03908-6)