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Study on the effect of chronic cholinergic stimulation with pyridostigmine bromide on cardiac autonomic adaptations induced by aerobic physical training in spontaneously hypertensive rats (SHR)

Grant number: 11/22513-4
Support Opportunities:Regular Research Grants
Duration: March 01, 2012 - February 28, 2014
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Hugo Celso Dutra de Souza
Grantee:Hugo Celso Dutra de Souza
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Cholinergic stimulation by means of acetylcholinesterase inhibition produces effects on the cardiac autonomic control resembling to those of aerobic physical training in both human and animal experimental models. These effects are mainly characterised by significant increase in heart rate variability (HRV) and baroreflex sensitivity. Up to now, however, no study has addressed the haemodynamic and autonomic effects of cholinergic stimulation on hypertension or its association with aerobic physical training. In this sense, our aim is to investigate haemodynamically and morphometrically the effect of cholinergic stimulation on the cardiovascular autonomic control in spontaneously hypertensive rats (SHR) by using an acetylcholinesterase inhibitor (pyridostigmine bromide) associated or not with aerobic physical training. This experimental model was chosen because spontaneously hypertensive rats are classically known to exhibit morphological and haemodynamic cardiac changes associated with impairment in cardiac autonomic tonus balance, decrease in baroreflex sensitivity, and modifications in the autonomic modulation of HRV, characterised by reduced influence of the vagal component and increased influence of the sympathetic component. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BLANCO, JOAO H. D.; GASTALDI, ADA C.; GARDIM, CAMILA B.; ARAUJO, JOAO E.; SIMOES, MARCUS V.; OLIVEIRA, LUCIANO F. L.; CARVALHO, EDUARDO E. V.; SOUZA, HUGO C. D.. Chronic cholinergic stimulation promotes changes in cardiovascular autonomic control in spontaneously hypertensive rats. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, v. 193, p. 97-103, . (11/22513-4)

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