| Grant number: | 11/22513-4 |
| Support Opportunities: | Regular Research Grants |
| Start date: | March 01, 2012 |
| End date: | February 28, 2014 |
| Field of knowledge: | Health Sciences - Physiotherapy and Occupational Therapy |
| Principal Investigator: | Hugo Celso Dutra de Souza |
| Grantee: | Hugo Celso Dutra de Souza |
| Host Institution: | Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
| City of the host institution: | Ribeirão Preto |
Abstract
Cholinergic stimulation by means of acetylcholinesterase inhibition produces effects on the cardiac autonomic control resembling to those of aerobic physical training in both human and animal experimental models. These effects are mainly characterised by significant increase in heart rate variability (HRV) and baroreflex sensitivity. Up to now, however, no study has addressed the haemodynamic and autonomic effects of cholinergic stimulation on hypertension or its association with aerobic physical training. In this sense, our aim is to investigate haemodynamically and morphometrically the effect of cholinergic stimulation on the cardiovascular autonomic control in spontaneously hypertensive rats (SHR) by using an acetylcholinesterase inhibitor (pyridostigmine bromide) associated or not with aerobic physical training. This experimental model was chosen because spontaneously hypertensive rats are classically known to exhibit morphological and haemodynamic cardiac changes associated with impairment in cardiac autonomic tonus balance, decrease in baroreflex sensitivity, and modifications in the autonomic modulation of HRV, characterised by reduced influence of the vagal component and increased influence of the sympathetic component. (AU)
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