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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Pyridostigmine Improves the Effects of Resistance Exercise Training after Myocardial Infarction in Rats

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Author(s):
Feriani, Daniele J. [1, 2] ; Coelho-Junior, Helio J. [2] ; de Oliveira, Juliana C. M. F. [1] ; Delbin, Maria A. [3] ; Mostarda, Cristiano T. [4] ; Dourado, Paulo M. M. [5] ; Caperuto, Erico C. [1] ; Irigoyen, Maria C. C. [5] ; Rodrigues, Bruno [2]
Total Authors: 9
Affiliation:
[1] Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo - Brazil
[2] Univ Estadual Campinas, Fac Phys Educ, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Dept Struct & Funct Biol, Inst Biol, Campinas, SP - Brazil
[4] Univ Fed Maranhao, Fac Phys Educ, Sao Luis - Brazil
[5] Univ Sao Paulo, Fac Med, Heart Inst InCor, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: FRONTIERS IN PHYSIOLOGY; v. 9, FEB 12 2018.
Web of Science Citations: 5
Abstract

Myocardial infarction (MI) remains the leading cause of morbidity and mortality worldwide. Exercise training and pharmacological treatments are important strategies to minimize the deleterious effects of MI. However, little is known about the effects of resistance training combined with pyridostigmine bromide (PYR) treatment on cardiac and autonomic function, as well as on the inflammatory profile after MI. Thus, in the present study, male Wistar rats were randomly assigned into: control (Cont); sedentary infarcted (10; PYR - treated sedentary infarcted rats (Inf+P); infarcted rats undergoing resistance exercise training (Inf+RT); and infarcted rats undergoing PYR treatment plus resistance training (Inf-FRT+P). After 12 weeks of resistance training (15-20 climbs per session, with a 1-min rest between each climb, at a low to moderate intensity, 5 days a week) and/or PYR treatment (0.14 mg/mL of drink water), hemodynamic function, autonomic modulation, and cytokine expressions were evaluated. We observed that 3 months of PYR treatment, either alone or in combination with exercise, can improve the deleterious effects of MI on left ventricle dimensions and function, baroreflex sensitivity, and autonomic parameters, as well as systemic and tissue inflammatory profile. Furthermore, additional benefits in a maximal load test and anti-inflammatory state of skeletal muscle were found when resistance training was combined with PYR treatment. Thus, our findings suggest that the combination of resistance training and PYR may be a good therapeutic strategy since they promote additional benefits on skeletal muscle anti-inflammatory profile after MI. (AU)

FAPESP's process: 14/19086-5 - Prior aerobic exercise training and cholinergic stimulation by pyridostigmine bromide in myocardial infarction: role in cardiac and autonomic function
Grantee:Nicolle Martins Carrozzi
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/14788-9 - Effects of exercise training and cholinergic stimulation with pyridostigmine bromide before and after myocardial infarction: role on cardiac and autonomic function, and inflammatory profile
Grantee:Bruno Rodrigues
Support Opportunities: Regular Research Grants
FAPESP's process: 14/03908-6 - Cardiac and autonomic adaptations to aerobic and resistance exercise training associated with cholinergic stimulation by pyridostigmine bromide in infarcted rats
Grantee:Daniele Jardim Feriani
Support Opportunities: Scholarships in Brazil - Master