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Analysis of central and peripheral muscle metabolism and adjustments on dynamic versus resistance exercise in coronary arterial disease patients: effects of resistance physical training program based on anaerobic threshold by different methodologies

Abstract

Introduction: Great emphasis has been placed on the prescription of aerobic physical exercises in cardiovascular rehabilitation (CR), however, although these are the most widely recommended, when one speaks of promoting health, there is a growing emphasis on resistance exercises in coronary arterial disease patients (CAD), which are essential for the performance of both occupational and recreational daily activities and leisure. However, the knowledgement of cardiocirculatory and peripheral metabolic adjusts in this modality has been poorly studied. Principal Objective: The objective of this study is to investigate the autonomic, ventilatory and metabolic adjustments in dynamic and resistance exercise in Leg Press 45° and compare the responses between healthy with coronary arterial disease subjects. Secondary objective is to determine a metabolic transitional point, as determined by lactataemia, heart rate and ventilatory variables, contrasting different intensities of resistance exercise. Additionally, a thirty objective is to verify if resistance physical exercise associated to aerobic training, based on anaerobic threshold can improve strength and muscle endurance in this patients. Study Design: Prospective study, longitudinal, controlled trial. Subjects: 20 male patients diagnosed with CAD, clinically stable, with at least 12 months since the acute event, after surgical or percutaneous revascularization and 6 months of CR with a functional capacity of >7.5 Mets and 10 healthy active volunteers matching in age (control group). Methods: The participants will undergo an incremental clinical test on ergometric cycle and a test of 1RM on a 45° leg-press, and subsequently, on separate days, a physical exercise on ergometric cycle with discontinuous dynamic exercise tests (DDET) with degrees of 10% of workload obtained during incremental test. Additionally, will be applied a resistance physical exercise tests (RPT) at different percents of 1MR, from which the HR, blood lactate and expired gas responses will be evaluated. Study Hypothesis: Autonomic responses during cicloergometer and resistance exercise would be associated to muscle metabolism during transitional fase of energy supply (anaerobic threshold) in subgroups studied, 2) metabolic responses during both physical exercise (ciclo and resistance) would be associated to ventilatory responses in both groups; 3) in DAC subjects, the ventilatory, cardiovascular and metabolic adjustments would occur early when comparing with healthy matched controls, 4) The methods to anaerobic threshold would be concordance between methods to determination of anaerobic threshold in dynamic and resistance exercise in both groups; 5) Resistance and aerobic training based on aerobic-anaerobic transition would improve endurance and strength and aerobic capacity in these patients. Study Relevance: The establishment of percentage of maximum resistance based on responses of HR and their HRV, lactataemia and expired gases, as well as how to detect AT through different methodologies will make it possible the knowledgement of physiological responses during different percentages of maximal resistance in healthy subjects and CAD patients and obtain practice foundation to prescription of resistance exercises and elaborate physical therapy treatment to reconditioning the peripheral musculature of these patients. (AU)

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Scientific publications (28)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BASSI-DIBAI, DANIELA; DIBAI-FILHO, ALMIR VIEIRA; CARVALHO, LIVIA PINHEIRO; DE MELO, BIANCA CARDOSO; PEDROSA, LETICIA BOMFIM; MENDES, RENATA GONCALVES; ROSSI CARUSO, FLAVIA CRISTINA; BORGHI-SILVA, AUDREY. Obesity, but not metabolic control, is associated with muscle strength and endurance in diabetic older adults. PHYSIOTHERAPY RESEARCH INTERNATIONAL, v. 25, n. 1, . (09/01842-0)
SANTOS-DE-ARAUJO, ALDAIR DARLAN; BASSI-DIBAI, DANIELA; VEIGA, THALITA PEREIRA; ROSSI CARUSO, FLAVIA CRISTINA; MENDES, RENATA GONCALVES; BONJORNO JUNIOR, JOSE CARLOS; ARENA, ROSS; SCHWARTZMANN, PEDRO VELLOSA; SIMOES, RODRIGO POLAQUINI; BORGHI-SILVA, AUDREY. Circulatory and ventilatory power in diabetic patients: Secondary analysis of a randomized controlled trial. PHYSIOTHERAPY RESEARCH INTERNATIONAL, . (09/01842-0)
ARAKELIAN, VIVIAN M.; MENDES, RENATA G.; TRIMER, RENATA; ROSSI CARUSO, FLAVIA C.; DE SOUSA, NUNO M.; BORGES, VANESSA C.; DO VALLE GOMES GATTO, CAMILA; BALDISSERA, VILMAR; ARENA, ROSS; BORGHI-SILVA, AUDREY. Critical load: a novel approach to determining a sustainable intensity during resistance exercise. JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS, v. 57, n. 5, p. 556-564, . (09/01842-0)
CARUSO, F. R.; ARENA, R.; PHILLIPS, S. A.; BONJORNO, JR., J. C.; MENDES, R. G.; ARAKELIAN, V. M.; BASSI, D.; NOGI, C.; BORGHI-SILVA, A.. Resistance exercise training improves heart rate variability and muscle performance: a randomized controlled trial in coronary artery disease patients. European Journal of Physical and Rehabilitation Medicine, v. 51, n. 3, p. 281-289, . (11/20074-3, 14/00530-2, 09/01842-0)
DI THOMMAZO-LUPORINI, LUCIANA; CARVALHO, LIVIA PINHEIRO; LUPORINI, RAFAEL LUIS; TRIMER, RENATA; FALASCO PANTONI, CAMILA BIANCA; MARTINEZ, ADALBERTO FELIPE; CATAI, APARECIDA MARIA; ARENA, ROSS; BORGHI-SILVA, AUDREY. Are cardiovascular and metabolic responses to field walking tests interchangeable and obesity-dependent?. DISABILITY AND REHABILITATION, v. 38, n. 18, p. 1820-1829, . (09/01842-0)
CARUSO, FLAVIA R.; BONJORNO, JR., JOSE C.; ARENA, ROSS; PHILLIPS, SHANE A.; CABIDDU, RAMONA; MENDES, RENATA G.; ARAKELIAN, VIVIAN M.; BASSI, DANIELA; BORGHI-SILVA, AUDREY. Hemodynamic, Autonomic, Ventilatory, and Metabolic Alterations After Resistance Training in Patients With Coronary Artery Disease. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, v. 96, n. 4, p. 226-235, . (11/20074-3, 09/01842-0)
BASSI, DANIELA; SANTOS-DE-ARAUJO, ALDAIR DARLAN; CAMARGO, PATRICIA FARIA; DIBAI-FILHO, ALMIR VIEIRA; DA FONSECA, MOYRANE ABREU; MENDES, RENATA GONCALVES; BORGHI-SILVA, AUDREY. Inter and Intra-Rater Reliability of Short-Term Measurement of Heart Rate Variability on Rest in Diabetic Type 2 Patients. JOURNAL OF MEDICAL SYSTEMS, v. 42, n. 12, . (09/01842-0)
ARAKELIAN, VIVIAN MARIA; GOULART, CASSIA DA LUZ; MENDES, RENATA GONCALVES; DE SOUSA, NUNO MANOEL; TRIMER, RENATA; GUIZILINI, SOLANGE; MALOSA SAMPAIO, LUCIANA MARIA; BALDISSERA, VILMAR; ARENA, ROSS; REIS, MICHEL S.; et al. Physiological responses in different intensities of resistance exercise - Critical load and the effects of aging process. JOURNAL OF SPORTS SCIENCES, v. 37, n. 12, p. 1420-1428, . (09/01842-0)
JUERGENSEN, SORAIA P.; TRIMER, RENATA; DOURADO, VICTOR Z.; DI THOMMAZO-LUPORINI, LUCIANA; BONJORNO-JUNIOR, JOSE C.; OLIVEIRA, CLAUDIO R.; ARENA, ROSS; MENDES, RENATA G.; BORGHI-SILVA, AUDREY. Shuttle walking test in obese women: test-retest reliability and concurrent validity with peak oxygen uptake. CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, v. 35, n. 2, p. 120-126, . (09/01842-0)
TRIMER, R.; CABIDDU, R.; MENDES, R. G.; COSTA, F. S. M.; OLIVEIRA, JR., A. D.; BORGHI-SILVA, A.; BIANCHI, A. M.. Heart Rate Variability and Cardio-respiratory Coupling During Sleep in Patients Prior to Bariatric Surgery. OBESITY SURGERY, v. 24, n. 3, p. 471-477, . (09/01842-0)
PAOLILLO, FERNANDA ROSSI; CORAZZA, ADALBERTO VIEIRA; BORGHI-SILVA, AUDREY; PARIZOTTO, NIVALDO ANTONIO; KURACHI, CRISTINA; BAGNATO, VANDERLEI SALVADOR. Infrared LED irradiation applied during high-intensity treadmill training improves maximal exercise tolerance in postmenopausal women: a 6-month longitudinal study. Lasers in Medical Science, v. 28, n. 2, p. 415-422, . (98/14270-8, 09/01842-0)
BORGHI-SILVA, AUDREY; BELTRAME, THOMAS; REIS, MICHEL SILVA; MALOSA SAMPAIO, LUCIANA MARIA; CATAI, APARECIDA MARIA; ARENA, ROSS; COSTA, DIRCEU. Relationship between oxygen consumption kinetics and BODE Index in COPD patients. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 7, p. 711-718, . (09/01842-0)
FLAVIA CRISTINA ROSSI CARUSO; RODRIGO POLAQUINI SIMÕES; MICHEL SILVA REIS; SOLANGE GUIZILINI; VERA LUCIA DOS SANTOS ALVES; VALERIA PAPA; ROSS ARENA; AUDREY BORGHI-SILVA. High-Intensity Inspiratory Protocol Increases Heart Rate Variability in Myocardial Revascularization Patients. Revista Brasileira de Cirurgia Cardiovascular, v. 31, n. 1, p. 38-44, . (09/01842-0)
PESSOA, BRUNA V.; BELTRAME, THOMAS; PIRES DI LORENZO, VALERIA A.; CATAI, APARECIDA M.; BORGHI-SILVA, AUDREY; JAMAMI, MAURICIO. COPD patients' oxygen uptake and heart rate on-kinetics at cycle-ergometer: correlation with their predictors of severity. BRAZILIAN JOURNAL OF PHYSICAL THERAPY, v. 17, n. 2, p. 152-162, . (09/01842-0)
BRUNO ARCHIZA; RODRIGO P. SIMÕES; RENATA G. MENDES; GUILHERME A. F. FREGONEZI; APARECIDA M. CATAI; AUDREY BORGHI-SILVA. Acute effects of different inspiratory resistive loading on heart rate variability in healthy elderly patients. BRAZILIAN JOURNAL OF PHYSICAL THERAPY, v. 17, n. 4, p. 401-408, . (09/01842-0)
SPERLING, MILENA PELOSI RIZK; CARUSO, FLAVIA CRISTINA ROSSI; MENDES, RENATA GONCALVES; DUTRA, DANIELA BASSI; ARAKELIAN, VIVIAN MARIA; BONJORNO, JR., JOSE CARLOS; CATAI, APARECIDA MARIA; ARENA, ROSS; BORGHI-SILVA, AUDREY. Relationship between non-invasive haemodynamic responses and cardiopulmonary exercise testing in patients with coronary artery disease. CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, v. 36, n. 2, p. 92-98, . (09/01842-0)
CARVALHO, LIVIA PINHEIRO; DI THOMMAZO-LUPORINI, LUCIANA; AUBERTIN-LEHEUDRE, MYLENE; BONJORNO JUNIOR, JOSE CARLOS; DE OLIVEIRA, CLAUDIO RICARDO; LUPORINI, RAFAEL LUIS; MENDES, RENATA GONCALVES; LOPES ZANGRANDO, KATIANY THAIS; TRIMER, RENATA; ARENA, ROSS; et al. Prediction of Cardiorespiratory Fitness by the Six-Minute Step Test and Its Association with Muscle Strength and Power in Sedentary Obese and Lean Young Women: A Cross-Sectional Study. PLoS One, v. 10, n. 12, . (09/01842-0, 15/12751-6, 13/15681-3)
TRIMER, R.; MENDES, R. G.; COSTA, F. S. M.; SAMPAIO, L. M. M.; DELFINO, JR., A.; ARENA, R.; ALETTI, F.; FERRARIO, M.; BORGHI-SILVA, A.. Is there a chronic sleep stage-dependent linear and nonlinear cardiac autonomic impairment in obstructive sleep apnea?. Sleep and Breathing, v. 18, n. 2, p. 403-409, . (09/01842-0)
PAOLILLO, F. R.; CORAZZA, A. V.; PAOLILLO, A. R.; BORGHI-SILVA, A.; ARENA, R.; KURACHI, C.; BAGNATO, V. S.. Phototherapy during treadmill training improves quadriceps performance in postmenopausal women. CLIMACTERIC, v. 17, n. 3, p. 285-293, . (98/14270-8, 09/01842-0, 08/57858-9)
PAOLILLO, FERNANDA ROSSI; ROSS, ARENA; DUTRA, DANIELA BASSI; MARQUETI DURIGAN, RITA DE CASSIA; DE ARAUJO, HELOISA SELISTRE; DUTRA DE SOUZA, HUGO CELSO; PARIZOTTO, NIVALDO ANTONIO; CIPRIANO, JR., GERSON; CHIAPPA, GASPAR; BORGHI-SILVA, AUDREY. Low-level Laser Therapy Associated With High Intensity Resistance Training on Cardiac Autonomic Control of Heart Rate and Skeletal Muscle Remodeling in Wistar Rats. Lasers in Surgery and Medicine, v. 46, n. 10, p. 796-803, . (09/01842-0, 13/14001-9, 13/07276-1)
RODRIGO P SIMÕES; JOSÉ C BONJORNO JR; THOMAS BELTRAME; APARECIDA M CATAI; ROSS ARENA; AUDREY BORGHI-SILVA. Resposta lentificada da cinética da frequência cardíaca e do consumo de oxigênio na transição on e off durante o teste de exercício descontínuo incremental: efeito do envelhecimento. BRAZILIAN JOURNAL OF PHYSICAL THERAPY, v. 17, n. 1, p. 69-76, . (09/01842-0)
SIMOES, R. P.; CASTELLO-SIMOES, V.; MENDES, R. G.; ARCHIZA, B.; SANTOS, D. A.; MACHADO, H. G.; BONJORNO, JR., J. C.; OLIVEIRA, C. R.; REIS, M. S.; CATAI, A. M.; et al. Lactate and Heart Rate Variability Threshold during Resistance Exercise in the Young and Elderly. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 34, n. 11, p. 991-996, . (09/01842-0)
MILENA P. R. SPERLING; RODRIGO P. SIMÕES; FLÁVIA C. R. CARUSO; RENATA G. MENDES; ROSS ARENA; AUDREY BORGHI-SILVA. Is heart rate variability a feasible method to determine anaerobic threshold in progressive resistance exercise in coronary artery disease?. BRAZILIAN JOURNAL OF PHYSICAL THERAPY, n. ahead, p. 0-0, . (09/01842-0)
PAOLILLO, FERNANDA ROSSI; MILAN, JULIANA CRISTINA; PAOLILLO, ALESSANDRA ROSSI; BRASILEIRO LOPES, SERGIO LUIZ; KURACHI, CRISTINA; BAGNATO, VANDERLEI SALVADOR; BORGHI-SILVA, AUDREY. Impact of fat distribution on metabolic, cardiovascular and symptomatic aspects in postmenopausal women. International Journal of Diabetes in Developing Countries, v. 34, n. 1, p. 32-39, . (98/14270-8, 09/01842-0)
MILENA P. R. SPERLING; RODRIGO P. SIMÕES; FLÁVIA C. R. CARUSO; RENATA G. MENDES; ROSS ARENA; AUDREY BORGHI-SILVA. Is heart rate variability a feasible method to determine anaerobic threshold in progressive resistance exercise in coronary artery disease?. BRAZILIAN JOURNAL OF PHYSICAL THERAPY, v. 20, n. 4, p. 289-297, . (09/01842-0)
TRIMER, R.; CABIDU, R.; SAMPAIO, L. L. M.; STIRBULOV, R.; POIARES, D.; GUIZILINI, S.; BIANCHI, A. M.; COSTA, F. S. M.; MENDES, R. G.; DELFINO, JR., A.; et al. Heart rate variability and cardiorespiratory coupling in obstructive sleep apnea: elderly compared with young. Sleep Medicine, v. 15, n. 11, p. 1324-1331, . (09/01842-0)
PAOLILLO, FERNANDA ROSSI; BORGHI-SILVA, AUDREY; ARENA, ROSS; PARIZOTTO, NIVALDO ANTONIO; KURACHI, CRISTINA; BAGNATO, VANDERLEI SALVADOR. Effects of phototherapy plus physical training on metabolic profile and quality of life in postmenopausal women. Journal of Cosmetic and Laser Therapy, v. 19, n. 6, p. 364-372, . (09/01842-0, 13/14001-9, 13/07276-1)
MARRARA, KAMILLA TAYS; PIRES DI LORENZO, VALERIA AMORIM; JAENISCH, RODRIGO B.; CABIDDU, RAMONA; SATO, TATIANA DE OLIVEIRA; MENDES, RENATA GONCALVES; OLIVEIRA, CLAUDIO R.; COSTA, DIRCEU; BORGHI-SILVA, AUDREY. Noninvasive Ventilation as an Important Adjunct to an Exercise Training Program in Subjects With Moderate to Severe COPD. Respiratory Care, v. 63, n. 11, p. 1388-1398, . (09/01842-0)

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Filed patent(s) as a result of this research project

CONSTRUCTIVE ARRANGEMENT INTRODUCED IN PORTABLE ERGOMETER WITH PERFORMANCE RECORDER AND SOFTWARE PCT/BR2016/000009 - Instituto Federal de Educação, Ciência e Tecnologia de São Paulo (IFSP) ; Universidade Federal de São Carlos (UFSCAR) . Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - January 2016, 08

DISPOSIÇÃO CONSTRUTIVA INTRODUZIDA EM DEGRAU ERGOMÉTRICO PORTÁTIL COM REGISTRADOR DE DESEMPENHO E SOFTWARE BR2020150006034 - Instituto Federal de Educação, Ciência e Tecnologia de São Paulo (IFSP) ; Universidade Federal de São Carlos (UFSCAR) . Audrey Borghi Silva; Luciana Di Thommazo Luporini; Daniel Braatz Antunes de Almeida Moura; Gislaine Ferreira Gonçalves; Jefferson Rodrigo Santos Pedro; Vinicius Valls Blanch Maimone Santos Zhu; Vanessa Fernandes; Pedro Northon Nobile; André Di Tommazo; Robson de Paula Teixeira - January 2015, 09