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Effects of a resistance exercise program based of determination of anaerobic threshold in increasing resistance testing in patients with coronary artery disease

Grant number: 11/20074-3
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): April 01, 2012
Effective date (End): May 01, 2015
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Audrey Borghi e Silva
Grantee:Flávia Cristina Rossi Caruso Bonjorno
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated scholarship(s):14/00530-2 - Effects of a resistance exercise program based on anaerobic threshold determination in patients with coronary artery disease, BE.EP.DD


Resistance Exercise (RE) promotes important changes in patients with Coronary Artery Disease (CAD). However, most studies use the ER as prescribed percentage of the maximum repetition without considering the hemodynamic and autonomic changes in this exercise intensity. The Anaerobic Threshold (AT) in the ER appears to be a safe intensity considering the autonomic and hemodynamic changes. However, if this intensity resistance exercise produces muscle an adaptation remains to be clarified. Objective: To evaluate the effects of progressive resistance training in cardiac function, muscle metabolism in patients with Coronary Artery Disease (CAD). Study Design: Prospective study, longitudinal, controlled trial, randomized. Subjects: 20 male patients diagnosed with CAD, clinically stable, with at least 12 months since the acute event, after surgical or percutaneous revascularization and 6 months of CR with a functional capacity of >7.5.Methods: The participants will undergo a test of 1RM on a 45° leg-press. Additionally, will be applied a Resistance Physical Exercise tests (RPT) at different percents of 1MR, from which the HR, blood lactate and expired gas responses will be evaluated. Study Hypothesis: Resistance training based on the aerobic-anaerobic transition adds benefits of improved endurance, muscle strength and modifies the autonomic control of heart rate. Study Relevance: The establishment of percentage of maximum resistance based on responses of HR and their HRV, lactataemia and expired gases, as well as how to detect AT through different methodologies will make it possible the knowledgement of physiological responses during different percentages of maximal resistance in CAD patients and obtain practice foundation to prescription of resistance exercises and elaborate physical therapy treatment to reconditioning the peripheral musculature in patients of coronary artery disease. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARUSO, FLAVIA ROSSI; BONJORNO JUNIOR, JOSE CARLOS; MENDES, RENATA G.; SPERLING, MILENA PELOSI; ARAKELIAN, VIVIAN M.; BASSI, DANIELA; ARENA, ROSS; BORGHI-SILVA, AUDREY. Hemodynamic and metabolic response during dynamic and resistance exercise in different intensities: a cross-sectional study on implications of intensity on safety and symptoms in patients with coronary disease. AMERICAN JOURNAL OF CARDIOVASCULAR DISEASE, v. 6, n. 2, p. 36-45, . (11/20074-3, 14/00530-2)
CARUSO, F. R.; ARENA, R.; PHILLIPS, S. A.; BONJORNO, JR., J. C.; MENDES, R. G.; ARAKELIAN, V. M.; BASSI, D.; NOGI, C.; BORGHI-SILVA, A.. Resistance exercise training improves heart rate variability and muscle performance: a randomized controlled trial in coronary artery disease patients. European Journal of Physical and Rehabilitation Medicine, v. 51, n. 3, p. 281-289, . (14/00530-2, 09/01842-0, 11/20074-3)
CARUSO, FLAVIA R.; BONJORNO, JR., JOSE C.; ARENA, ROSS; PHILLIPS, SHANE A.; CABIDDU, RAMONA; MENDES, RENATA G.; ARAKELIAN, VIVIAN M.; BASSI, DANIELA; BORGHI-SILVA, AUDREY. Hemodynamic, Autonomic, Ventilatory, and Metabolic Alterations After Resistance Training in Patients With Coronary Artery Disease. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, v. 96, n. 4, p. 226-235, . (11/20074-3, 09/01842-0)
CARUSO, FLAVIA ROSSI; BONJORNO JUNIOR, JOSE CARLOS; MENDES, RENATA GONCALVES; ARAKELIAN, VIVIAN MARIA; TRIMER, RENATA; BASSI, DANIELA; BORGHI-SILVA, AUDREY. Resistance Training Of 8 Weeks Improve Heart Rate Variability In Cardiac Patients - A Randomized Controlled Trial. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 47, n. 5, p. 1-pg., . (09/01842-0, 11/20074-3)

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