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Effects of a semi-supervised home-based exercise training on physical performance, biological and mental outcomes on primary lung cancer patients: a randomized clinical trial

Grant number: 19/16004-1
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2021
Effective date (End): July 28, 2024
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Ercy Mara Cipulo Ramos
Grantee:Isis Grigoletto Silva
Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
Associated scholarship(s):22/04801-7 - Effects of different interventions in people with lung, head, and neck cancer and people after bone marrow transplant and an analysis of prognostic significance of physical activity and sedentary behaviour in lung cancer, BE.EP.DR


Introduction: Lung cancer is known for its high prevalence and mortality rates. Chemotherapy and/or radiotherapy are usually recommended as the main treatment(s) for this disease; however they can negatively impact both the physical and mental status of patients. Hence, it is reasonable to consider resistance and/or aerobic exercise training to prevent the impact of the disease and its treatment(s). Further, several factor prevent patients to attend outpatient exercise training programs and, therefore, a semi-supervised home-based exercise training program could be well accepted. Aims: To investigate in people with primary lung cancer the protective effect of a semi-supervised home-based exercise training (resistance and aerobic) on physical performance, biological and mental outcomes, prevention of the reduction of the initial oncological treatment dose prescribed, number of hospitalizations in three, six and nine months and on 12-month survival. Methods: Participants with primary lung cancer will be randomized into: TG: Training Group and CG: Control Group. The TG will undergo semi-supervised home-based aerobic and resistance exercise training during their usual oncology treatment (radiotherapy and/or chemotherapy) period. This intervention will start one week before the usual oncology treatment, will be performed throughout the duration of the treatment and will continue for two weeks after treatment completion. The CG will undergo usual oncology treatment. Assessment will take place two weeks before the beginning of the usual oncology treatment and two weeks after treatment completion. Measures will be collected of: physical outcomes (muscle strength, functional capacity and physical activity level), biological parameters (body composition) and mental (symptoms of anxiety and depression, quality of life and symptoms related to the disease and treatment). We will also assess satisfaction with the intervention, hospitalization in 3,6 and 9 months, survival in 12 months and any change in dose of oncological treatment. Statistical Analysis: The data normality will be verified by the Kolmogorov-Smirnov test. For intra and inter-group analyzes of the basal and final moments of GT and CG, t Student test or Mann-Whitney test will be used, according to the normality of data.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GRIGOLETTO, ISIS; CAVALHERI, VINICIUS; GOBBO, LUIS ALBERTO; POZO, KARINA; FILHO, ENIO RODRIGUES MAIA; RIBEIRO, DIOGO GONCALVES; IELO, NARA; DE LIMA, FABIANO FRANCISCO; RAMOS, ERCY MARA CIPULO. Effects of Semisupervised Exercise Training on Health Outcomes in People With Lung or Head and Neck Cancer: Protocol for a Randomized Controlled Trial. JMIR RESEARCH PROTOCOLS, v. 12, p. 10-pg., . (21/06065-3, 19/16004-1)
UZELOTO, J.; DE TOLEDO-ARRUDA, A. C.; SILVA, SPOLADOR DE ALENCAR B.. Effect of physical training on cytokine expression in CD4+ T lymphocytes in subjects with stable COPD (vol 16, pg 1, 2022). THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE, v. 16, p. 1-pg., . (19/16004-1, 17/10145-7, 21/04198-6, 18/04870-3)

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