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Effects of different interventions in people with lung, head, and neck cancer and people after bone marrow transplant and an analysis of prognostic significance of physical activity and sedentary behaviour in lung cancer

Grant number: 22/04801-7
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): December 01, 2022
Effective date (End): November 30, 2023
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Ercy Mara Cipulo Ramos
Grantee:Isis Grigoletto Silva
Supervisor: Vinicius Cavalheri de Oliveira
Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
Research place: Curtin University, Australia  
Associated to the scholarship:19/16004-1 - Effects of a semi-supervised home-based exercise training on physical performance, biological and mental outcomes on primary lung cancer patients: a randomized clinical trial, BP.DR


Introduction: High prevalence and mortality rates are presented in lung, head and neck cancers. Chemotherapy and/or radiotherapy are usually recommended as the main treatment(s) for these malignancies, however, they can negatively impact both the physical and mental status of patients. Therefore, it is reasonable to consider resistance and/or aerobic exercise training to prevent these negative health outcomes. Further, several factors prevent patients from attending outpatient exercise training programs and, therefore, a semi-supervised home-based exercise training program may be seen as a well-accepted alternative. Besides that, there is still a scarceness of research on physical activity and sedentary behaviour in lung cancer. Reduced physical activity and increased sedentary behaviour are associated with increased mortality in colorectal and breast cancers. Therefore, the association between physical activity, sedentary behaviour and mortality in people with lung cancer need to be well investigated. Aims: 1) To perform analyses of a randomized clinical trial (RCT) that investigated the effects of a semi-supervised home-based exercise training program on physical, biological and mental characteristics, changes on the initial cancer treatment dose prescribed, number of hospitalizations in three, six and nine months as well as on 12-month survival in people with primary lung or head and neck cancer, and 2) To perform analyses of a study that investigated clinical and physical outcomes in people recently diagnosed with inoperable lung cancer and the prognostic value of sedentary behaviour and physical activity to predict 12-month mortality. Methods: Data from the RCT will be organized and the statistical analysis will be performed as follow: to attend the primary aim, the data normality will be verified by the Kolmogorov-Smirnov test. For intra and inter-group analyzes of the basal and final moments of GT and CG, t Student test or Mann-Whitney test will be used, according to the normality of data. Regarding the second aim, Kaplan-Meier survival plots will be used to investigate the influence of physical activity and sedentary behaviour on all-cause mortality and the relative risk of mortality will be investigated using multivariate Cox proportional hazard analyses. Linear regression models will be used to estimate the associations between time spent in sedentary behaviour or physical activity with the other variables. A p value d 0.05 will denote statistical significance. Posteriorly, the discussion of the results from the RCT and from the second study, will be performed. (AU)

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