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Maternal separation affects cocaine-induced locomotion and response to novelty in adolescent‚ but not in adult rats

Texto completo
Autor(es):
Marin‚ M. T. ; Planeta‚ C. S.
Número total de Autores: 2
Tipo de documento: Artigo Científico
Fonte: Brain Research; v. 1013, n. 1/2, p. 83-90, 2004.
Área do conhecimento: Ciências Biológicas - Farmacologia
Assunto(s):Farmacologia   Neuroendocrinologia   Comportamento animal   Estresse   Transtornos relacionados ao uso de substâncias   Cocaína
Resumo

Maternal separation is known to exert long-term effects on both behavior and the neuroendocrine system. We investigated cocaine-induced locomotor activation as well as the locomotor and corticosterone response to forced novelty in maternally separated adolescent and adult rats. Maternal separation consisted of separating litters from their dams daily during 5 h from postnatal days 2 to 6. Control animals were subjected only to regular cage changes. Cocaine- (10 mg/kg, i.p.) and novelty-induced locomotion were recorded in an activity cage. After the animals were tested for behavioral response to novelty, trunk blood samples were collected and plasma corticosterone levels were determined by radioimmunoassay. Adolescent rats exposed to maternal separation exhibited an increased locomotor response to novelty and cocaine; corticosterone levels were lower in these adolescent animals, after exposure to the novel environment. These effects of maternal separation were not observed in rats that were tested as adults. Thus the maternal separation protocol produced enduring but transient changes in the behavioral response to cocaine and in the stress response to novelty. (AU)

Processo FAPESP: 00/09319-0 - Efeito da separação materna na sensibilização comportamental induzida pela cocaína
Beneficiário:Marcelo Tadeu Marin
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 97/11010-2 - Exposição ao estresse durante o desenvolvimento: consequências sobre os efeitos comportamentais e moleculares da cocaína em ratos
Beneficiário:Cleopatra da Silva Planeta
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores