Antiprotozoal, Schistosomicidal, and Antimicrobial Activities of the Essential Oil from the Leaves of Baccharis dracunculifolia

Autor(es):Mostrar menos -

Parreira, Natallia A. ^[1] ; Magalhaes, Lizandra C. ^[2] ; Morais, Denis R. ^[1] ; Caixeta, Soraya C. ^[1] ; de Sousa, Joao P. B. ^[3] ; Bastos, Jairo K. ^[3] ; Cunha, Wilson R. ^[1] ; Silva, Marcio L. A. ^[1] ; Nanayakkara, N. P. D. ^[4] ; Rodrigues, Vanderlei ^[2] ; da Silva Filho, Ademar A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Franca, Lab Prod Nat Nucl Pesquisa Ciencias Exatas & Tecn, BR-14404600 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo - Brazil

^[4] Univ Mississippi, Natl Ctr Nat Prod Res, Pharmaceut Sci Res Inst, Sch Pharm, Oxford, MS - USA

• Tipo de documento: Artigo Científico
• Fonte: CHEMISTRY & BIODIVERSITY; v. 7, n. 4, p. 993-1001, 2010.
• Citações Web of Science: 57

Resumo

Baccharis dracunculifolia DC. (Asteraceae), popularly known as alecrim do campo, is a native plant from Brazil used in folk medicine as febrifuge, anti-inflammatory, antiseptic, and to treat skin sores. Also, B. dracanculifolia is the most important plant source of the Brazilian green propolis. which is recognized for its antiseptic and antiprotozoal activities. This study aimed at investigating the in vitro antiprotozoal. schistosomicidal, and antimicrobial activities of the essential oil from the leaves of R. dracunculifolia. The essential oil was obtained by hydrodistillation and analyzed by CC and GC/MS, which allowed the identification of 14 compounds, mainly oxygenated sesquiterpenes, such as ( E)nerolidol (33.51%) and spathulenol (16.24%). The essential oil showed activity against promzistigote forms of Leishmania donovani, with IC50, values of 42 mu g/ml. The essential oil displayed high activity in the schistosomicidal assay, since all pairs of Schistosoma mansoni adult worms were dead after incubation with the essential oil (10, 50, and 100 fig/m1). B. dracunculifolia essential oil was neither cytotoxic against Vero cells, nor active in the antimicrobial and antiplasmodial assays. (AU)

• Processo FAPESP: 06/60132-4 - Investigação das atividades esquistossomicida, tripanocida e leishmanicida de lignanas e neolignanas obtidas por acoplamento oxidativo in vitro de fenilpropanóides
• Beneficiário: Ademar Alves da Silva Filho
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 09/05478-0 - Avaliação in vitro da citotoxicidade e da atividade esquistossomicida de algumas naftaquinonas sintéticas.
• Beneficiário: Natallia Alle Parreira
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico