Nitric oxide: a potential inducer of adhesion-related apoptosis-anoikis

Autor(es)

Monteiro, H. P. ; Silva, E. F. ; Stern, A.

• Tipo de documento: Artigo Científico
• Fonte: NITRIC OXIDE-BIOLOGY AND CHEMISTRY; v. 10, n. 1, p. 1-10, Feb. 2004.
• Área do conhecimento: Ciências da Saúde - Medicina
• Assunto(s): Matriz extracelular Citofisiologia Adesão celular Morte celular Apoptose Anoikis Óxido nítrico

Resumo

Among the many initiating events that lead to apoptosis or programmed cell death, loss of contact between the cell and the extracellular matrix has been extensively studied. Adhesion-related apoptosis referred to as anoikis is initiated by the action of anti-adhesive substances. Nitric oxide is one of these anti-adhesive substances that have the capacity to signal and trigger pro-apoptotic events in a variety of cell types. Nitric oxide can inhibit cell adhesion, interfere with the assembly of focal adhesion complexes, and disrupt the cell-extracellular matrix interactions. These actions occur in cell that exhibit a dissociation of growth factor signals from alterations in the cytoskeleton, ultimately leading to apoptosis. Since this involves anti-adhesive events, nitric oxide can be considered as causing anoikis. This review article summarizes the available evidence of how nitric oxide participates in apoptosis induced by loss of anchorage (anoikis). (AU)

• Processo FAPESP: 00/12154-2 - Fisiologia molecular da sinalização redox no sistema vascular e modelos de células em cultura
• Beneficiário: Francisco Rafael Martins Laurindo
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 99/11017-2 - O óxido nítrico como agente sinalizador na proliferação de células endoteliais
• Beneficiário: Hugo Pequeno Monteiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular