Q36R polymorphism of KiSS-1 gene in Brazilian head and neck cancer patients

Autor(es)

Ruiz, Mariangela Torreglosa ^{[1, 2]} ; Silva Galbiatti, Ana Livia ^[2] ; Pavarino, Erika Cristina ^[2] ; Maniglia, Jose Victor ^[3] ; Goloni-Bertollo, Eny Maria ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Triangulo Mineiro, BR-38025440 Uberaba, MG - Brazil

^[2] Fac Med Sao Jose do Rio Preto FAMERP, Genet & Mol Biol Res Unit UPGEM, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil

^[3] Fac Med Sao Jose do Rio Preto FAMERP, Otorhinolaryngol & Head & Neck Surg Dept, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MOLECULAR BIOLOGY REPORTS; v. 39, n. 5, p. 6029-6034, MAY 2012.
• Citações Web of Science: 2
• Assunto(s): Polimorfismo genético Neoplasias de cabeça e pescoço

Resumo

The KiSS-1 metastasis-suppressor gene (KiSS-1) product (metastin, kisspeptin) is reported to act after binding with the natural ligand of a G-protein coupled receptor and this gene product inhibits chemotaxis, invasion, and metastasis of cells. The aim of this study was to evaluate the Q36R polymorphism of KiSS-1 in patients with head and neck cancer and to compare the results with healthy individuals and its association with clinicopathological parameters. Gender, age, smoking and alcohol consumption were analyzed for 744 individual (252 head and neck cancer patients and in 522 control individuals). The molecular analysis of these individuals was made after extraction of genomic DNA using the SSCP-PCR technique. This study did not reveal any significant differences in genotype frequencies between healthy individuals and patients with head and neck cancer or with the clinical parameters. This study showed an increase frequency of the Q36R polymorphism in pharyngeal cancer. (AU)

• Processo FAPESP: 04/14573-3 - Polimorfismos de nucleotideos unicos (snps) em pacientes com cancer de cabeca e pescoco.
• Beneficiário: Eny Maria Goloni Bertollo
• Modalidade de apoio: Auxílio à Pesquisa - Regular