Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Q36R polymorphism of KiSS-1 gene in Brazilian head and neck cancer patients

Full text
Author(s):
Ruiz, Mariangela Torreglosa [1, 2] ; Silva Galbiatti, Ana Livia [2] ; Pavarino, Erika Cristina [2] ; Maniglia, Jose Victor [3] ; Goloni-Bertollo, Eny Maria [2]
Total Authors: 5
Affiliation:
[1] Univ Fed Triangulo Mineiro, BR-38025440 Uberaba, MG - Brazil
[2] Fac Med Sao Jose do Rio Preto FAMERP, Genet & Mol Biol Res Unit UPGEM, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[3] Fac Med Sao Jose do Rio Preto FAMERP, Otorhinolaryngol & Head & Neck Surg Dept, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: MOLECULAR BIOLOGY REPORTS; v. 39, n. 5, p. 6029-6034, MAY 2012.
Web of Science Citations: 2
Abstract

The KiSS-1 metastasis-suppressor gene (KiSS-1) product (metastin, kisspeptin) is reported to act after binding with the natural ligand of a G-protein coupled receptor and this gene product inhibits chemotaxis, invasion, and metastasis of cells. The aim of this study was to evaluate the Q36R polymorphism of KiSS-1 in patients with head and neck cancer and to compare the results with healthy individuals and its association with clinicopathological parameters. Gender, age, smoking and alcohol consumption were analyzed for 744 individual (252 head and neck cancer patients and in 522 control individuals). The molecular analysis of these individuals was made after extraction of genomic DNA using the SSCP-PCR technique. This study did not reveal any significant differences in genotype frequencies between healthy individuals and patients with head and neck cancer or with the clinical parameters. This study showed an increase frequency of the Q36R polymorphism in pharyngeal cancer. (AU)