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Polymorphism analysis of the CYP2E1, ABCB1, ABCC2, OCT2 and MATE1 genes involved in the major adverse effects of cisplatin treatment of the Head and Neck Cancer

Grant number: 17/17245-7
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2018
Effective date (End): September 30, 2021
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Patricia Moriel
Grantee:Maria Aparecida Cursino
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):19/17040-1 - POLYGENIC RISK SCORES OF CISPLATIN-MEDIATED TOXICITY, BE.EP.DR

Abstract

Head and Neck Cancer (HNC) is the set of tumors that have mostly origin in squamous cells. It ranks 6th among the most common cancers in the world and each year, it is estimated that more than 633,000 new cases are diagnosed. Approximately 75% of the cases present the disease in an advanced stage (III and IV), for which the prognosis is poor. In the usual treatment, cisplatin chemotherapy has been used concomitantly with radiotherapy for inoperable carcinomas and it has been related to better survival and adherence to therapy, and case-by-case assessment is required due to the occurrence of severe adverse effects that limit the therapy, especially those related to nephrotoxicity. This study will verify the relationship of genetic polymorphisms of cytochrome P450 enzymes and carriers of ABC, OCT2 and MAPE1 families with plasma oxidative stress and toxicity induced by cisplatin treatment in patients with Head and Neck Cancer. Therefore, this study aims to provide tools to improve the treatment of patients with Head and Neck Cancer submitted to cisplatin therapy in the context of personalized medicine. For this, we will use blood and urine samples to determine the toxicity charts, as well as oxidative stress. Through q-PCR the genetic profiles of the cited genes will be determined and the data will be correlated. It is hoped that the results obtained will enable biomarkers of toxicity to be available in the future. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE GODOY TORSO, NADINE; VISACRI, MARILIA BERLOFA; QUINTANILHA, JULIA COELHO FRANCA; CURSINO, MARIA APARECIDA; PINCINATO, EDER DE CARVALHO; MORIEL, PATRICIA. Assessment of Renal Function in Head and Neck Cancer Patients Treated with Cisplatin: Different Biomarkers and Acute Kidney Injury Classifications. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 1, p. 18-pg., . (19/20010-7, 17/17245-7, 17/02338-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CURSINO, Maria Aparecida. Analysis of CYP2E1, ABCB1, ABCC2, OCT2 and MATE1 gene polymorphisms in the main cisplatin-mediated toxicity in the treatment of head and neck cancer. 2022. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

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