1H NMR Spectra. Part 28: Proton chemical shifts and couplings in three-membered rings. A ring current model for cyclopropane and a novel dihedral angle dependence for 3JHH couplings involving the epoxy proton

Autor(es)

Abraham, Raymond J. ^[1] ; Leonard, Paul ^[1] ; Tormena, Claudio F. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside - England

^[2] Univ Estadual Campinas, UNICAMP, Dept Organ Chem, Inst Chem, BR-13084971 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Magnetic Resonance in Chemistry; v. 50, n. 4, p. 305-313, APR 2012.
• Citações Web of Science: 18

Resumo

The 1H chemical shifts of selected three-membered ring compounds in CDCl3 solvent were obtained. This allowed the determination of the substituent chemical shifts of the substituents in the three-membered rings and the long-range effect of these rings on the distant protons. The substituent chemical shifts of common substituents in the cyclopropane ring differ considerably from the same substituents in acyclic fragments and in cyclohexane and were modelled in terms of a three-bond (gamma)-effect. For long-range protons (more than three bonds removed), the substituent effects of the cyclopropane ring were analysed in terms of the cyclopropane magnetic anisotropy and steric effect. The cyclopropane magnetic anisotropy (ring current) shift was modelled by (a) a single equivalent dipole perpendicular to and at the centre of the cyclopropane ring and (b) by three identical equivalent dipoles perpendicular to the ring placed at each carbon atom. Model (b) gave a more accurate description of the 1H chemical shifts and was the selected model. After parameterization, the overall root mean square error for the dataset of 289 entries was 0.068 ppm. The anisotropic effects are significant for the cyclopropane protons (ca 1 ppm) but decrease rapidly with distance. The heterocyclic rings of oxirane, thiirane and aziridine do not possess a ring current. 3JHH couplings of the epoxy ring proton with side-chain protons were obtained and shown to be dependent on both the H-C-C-H and H-C-C-O orientations. Both density functional theory calculations and a simple Karplus-type equation gave general agreement with the observed couplings (root mean square error 0.5 Hz over a 10-Hz range). Copyright (c) 2012 John Wiley \& Sons, Ltd. (AU)

• Processo FAPESP: 10/10993-9 - Estudo do mecanismo de transmissão de constantes de acoplamento escalar através do espaço
• Beneficiário: Claudio Francisco Tormena
• Modalidade de apoio: Auxílio à Pesquisa - Regular