Erysothrine, an alkaloid extracted from flowers of Erythrina mulungu Mart. ex Benth: Evaluating its anticonvulsant and anxiolytic potential

Autor(es)

Rosa, Daiane Santos ^[1] ; Faggion, Silmara Aparecida ^[1] ; Gavin, Amanda Salomao ^[1] ; de Souza, Maicon Anderson ^[1] ; Fachim, Helene Aparecida ^[2] ; dos Santos, Wagner Ferreira ^[2] ; Pereira, Ana Maria Soares ^[1] ; Cunha, Alexandra Olimpio Siqueira ^[3] ; Beleboni, Rene Oliveira ^[1]

Afiliação do(s) autor(es)

^[1] Univ Ribeirao Preto, Dept Biotechnol, Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, FFCLRP, Dept Biol, Sao Paulo - Brazil

^[3] Univ Sao Paulo, FMRP, Dept Physiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Epilepsy & Behavior; v. 23, n. 3, p. 205-212, MAR 2012.
• Citações Web of Science: 18

Resumo

In this study, we isolated the alkaloid erysothrine from the hydroalcoholic extract of flowers from E. mulungu and screened for its anticonvulsant and anxiolytic actions based on neuroethological and neurochemical experiments. Our results showed that the administration of erysothrine inhibited seizures evoked by bicuculline, PTZ, NMDA and most remarkably, kainic acid. Also, erysothrine induced an increase in the number of entries but not in the time spent in the open arms of the EPM. However, we did not notice any alterations in the light-dark choice or in the open-field tests. In preliminary neurochemistry tests, we also showed that erysothrine (0.001-10 mu g/mL) did not alter the GABA or glutamate synaptossomal uptake and binding. Altogether, our results describe an alkaloid with anticonvulsant activity and mild anxiolytic activity that might be considered well tolerated as it does not alter the general behavior of the animals in the used doses. (C) 2012 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 08/52627-9 - Determinação do potencial anticonvulsiovante e caracterização do mecanismo de ação neuroquímico de alcalóides isolados do extrato hidroalcoólico de flores da planta Erythrina mulungu (Leguminosae-Papilionaceae)
• Beneficiário: Silmara Aparecida Faggion
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 09/11357-1 - Caracterização neuroetológica e neuroquímica de alcalóides isolados do extrato hidroalcoólico de flores da planta Erythrina mulungu (Leguminosae-Papilionaceae)
• Beneficiário: Renê de Oliveira Beleboni
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/05200-0 - Avaliação da atividade ansiolítica e analgésica do alcalóide erisotrina isolado das flores da planta Erythrina mulungu (Leguminosae-Papilionaceae).
• Beneficiário: Daiane Santos Rosa Aguiar
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico