Nandrolone Inhibits MMP-2 in the Left Ventricle of Rats

Autor(es)

Marqueti, R. C. ^[1] ; Micocci, K. C. ^[1] ; Leite, R. D. ^[1] ; Selistre-de-Araujo, H. S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, BR-13565905 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF SPORTS MEDICINE; v. 33, n. 3, p. 181-185, MAR 2012.
• Citações Web of Science: 5

Resumo

The indiscriminate use of anabolic-androgenic steroids has been shown to induce left ventricular dysfunctions. The main objective of the present study was to investigate the effects of nandrolone decanoate on matrix metalloprotease (MMP-2) activity and protein level in the left ventricle (LV) of rats after 7 weeks of mechanical load exercise. Wistar rats were grouped into: sedentary (S); nandrolone decanoate-treated sedentary (AAS); trained without AAS (T) and trained and treated with AAS (AAST). Exercised groups performed a 7-weeks water-jumping program. Training significantly increased the MMP-2 activity by zymography and the protein level by Western blotting analysis. However, the AAS treatment abolished both the increase in MMP activity and protein level induced by exercise. These results suggest that AAS may impair cardiac tissue remodeling which may lead to the heart malfunction. (AU)

• Processo FAPESP: 06/50986-6 - Estudo de remodelamento do tendao calcaneo, tendao flexor profundo e tendao flexor superficial de ratos sob administracao de esteroide anabolico androgenico e exercicio de carga.
• Beneficiário: Rita de Cássia Marqueti Durigan
• Modalidade de apoio: Bolsas no Brasil - Doutorado