An in-depth analysis of the HIV-1/AIDS dynamics by comprehensive mathematical modeling

Autor(es)

Joly, Marcel ^{[1, 2]} ; Pinto, Jose M. ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Chem Engn, BR-05508900 Sao Paulo - Brazil

^[2] Petr Brasileiro SA, Petrobras - Brazil

^[3] Polytech Univ, Othmer Jacobs Dept Chem & Biol Engn, Brooklyn, NY 11201 - USA

• Tipo de documento: Artigo Científico
• Fonte: Mathematical and Computer Modelling; v. 55, n. 3-4, p. 342-366, FEB 2012.
• Citações Web of Science: 9

Resumo

This work presents major results from a novel dynamic model intended to deterministically represent the complex relation between HIV-1 and the human immune system. The novel structure of the model extends previous work by representing different host anatomic compartments under a more in-depth cellular and molecular immunological phenomenology. Recently identified mechanisms related to HIV-1 infection as well as other well known relevant mechanisms typically ignored in mathematical models of HIV-1 pathogenesis and immunology, such as cell-cell transmission, are also addressed. (C) 2011 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 99/09897-4 - Metodologias para a operação de Scheduling ótimos de sistemas reativos em batelada
• Beneficiário: Marcel Joly
• Linha de fomento: Bolsas no Brasil - Doutorado