Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An in-depth analysis of the HIV-1/AIDS dynamics by comprehensive mathematical modeling

Full text
Author(s):
Joly, Marcel [1, 2] ; Pinto, Jose M. [1, 3]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Dept Chem Engn, BR-05508900 Sao Paulo - Brazil
[2] Petr Brasileiro SA, Petrobras - Brazil
[3] Polytech Univ, Othmer Jacobs Dept Chem & Biol Engn, Brooklyn, NY 11201 - USA
Total Affiliations: 3
Document type: Journal article
Source: Mathematical and Computer Modelling; v. 55, n. 3-4, p. 342-366, FEB 2012.
Web of Science Citations: 9
Abstract

This work presents major results from a novel dynamic model intended to deterministically represent the complex relation between HIV-1 and the human immune system. The novel structure of the model extends previous work by representing different host anatomic compartments under a more in-depth cellular and molecular immunological phenomenology. Recently identified mechanisms related to HIV-1 infection as well as other well known relevant mechanisms typically ignored in mathematical models of HIV-1 pathogenesis and immunology, such as cell-cell transmission, are also addressed. (C) 2011 Elsevier Ltd. All rights reserved. (AU)