Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An in-depth analysis of the HIV-1/AIDS dynamics by comprehensive mathematical modeling

Full text
Joly, Marcel [1, 2] ; Pinto, Jose M. [1, 3]
Total Authors: 2
[1] Univ Sao Paulo, Dept Chem Engn, BR-05508900 Sao Paulo - Brazil
[2] Petr Brasileiro SA, Petrobras - Brazil
[3] Polytech Univ, Othmer Jacobs Dept Chem & Biol Engn, Brooklyn, NY 11201 - USA
Total Affiliations: 3
Document type: Journal article
Source: Mathematical and Computer Modelling; v. 55, n. 3-4, p. 342-366, FEB 2012.
Web of Science Citations: 9

This work presents major results from a novel dynamic model intended to deterministically represent the complex relation between HIV-1 and the human immune system. The novel structure of the model extends previous work by representing different host anatomic compartments under a more in-depth cellular and molecular immunological phenomenology. Recently identified mechanisms related to HIV-1 infection as well as other well known relevant mechanisms typically ignored in mathematical models of HIV-1 pathogenesis and immunology, such as cell-cell transmission, are also addressed. (C) 2011 Elsevier Ltd. All rights reserved. (AU)