Genetic analyses of smoking initiation, persistence, quantity, and age-at-onset of regular cigarette use in Brazilian families: the Baependi Heart Study

Autor(es)

Horimoto, Andrea R. V. R. ^[1] ; Oliveira, Camila M. ^[1] ; Giolo, Suely R. ^[2] ; Soler, Julia P. ^[3] ; de Andrade, Mariza ^[4] ; Krieger, Jose E. ^[1] ; Pereira, Alexandre C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Lab Genet & Mol Cardiol, Inst Heart, Sch Med, BR-05403000 Sao Paulo - Brazil

^[2] Univ Fed Parana, Dept Stat, Polytech Ctr, BR-81531990 Curitiba, PR - Brazil

^[3] Univ Sao Paulo, Dept Stat, Math & Stat Inst, BR-05508090 Sao Paulo - Brazil

^[4] Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 - USA

• Tipo de documento: Artigo Científico
• Fonte: BMC MEDICAL GENETICS; v. 13, JAN 30 2012.
• Citações Web of Science: 13

Resumo

Background: The purpose of this study was to estimate the genetic influences on the initiation of cigarette smoking, the persistence, quantity and age-at-onset of regular cigarette use in Brazilian families. Methods: The data set consisted of 1,694 individuals enrolled in the Baependi Heart Study. The heritability and the heterogeneity in genetic and environmental variance components by gender were estimated from variance components approaches, using the SOLAR (Sequential Oligogenic Linkage Analysis Routines) computer package. The mixed-effects Cox model was used for the genetic analysis of the age-at onset of regular cigarette use. Results: The heritability estimates were high (> 50%) for smoking initiation and were intermediate, ranging from 23.4 to 31.9%, for smoking persistence and quantity. Significant evidence for heterogeneity in variance components by gender was observed for smoking initiation and age-at-onset of regular cigarette use. Genetic factors play an important role in the interindividual variation of these phenotypes in females, while in males there is a predominant environmental component, which could be explained by greater social influences in the initiation of tobacco use. Conclusions: Significant heritabilities were observed in smoking phenotypes for both males and females from the Brazilian population. These data add to the literature and are concordant with the notion of significant biological determination in smoking behavior. Samples from the Baependi Heart Study may be valuable for the mapping of genetic loci that modulate this complex biological trait. (AU)

• Processo FAPESP: 07/58150-7 - Mapeamento genético de fatores de risco cardiovascular na população brasileira: uma abordagem de mapeamento baseada em núcleos familiares: Projeto Corações de Baependi
• Beneficiário: José Eduardo Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/51010-8 - Estudos de associacao genomica ampla de fatores de risco associados a doencas cardiovasculares em uma amostra populacional brasileira.
• Beneficiário: Andréa Roseli Vançan Russo Horimoto
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado