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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Changes in autonomic control of the cardiovascular system in the Wistar audiogenic rat (WAR) strain

Texto completo
Autor(es):
Fazan, Jr., Rubens [1] ; de Oliveira, Mauro [1] ; Oliveira, Jose Antonio C. [1] ; Salgado, Helio C. [1] ; Garcia-Cairasco, Norberto [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Epilepsy & Behavior; v. 22, n. 4, p. 666-670, DEC 2011.
Citações Web of Science: 15
Resumo

We evaluated autonomic cardiovascular modulation and baroreflex control of heart rate (HR) in a particular epileptic rat strain, Wistar audiogenic rats (WARs). We studied spontaneous baroreflex sensitivity as well as reflex changes in HR evoked by phenylephrine/nitroprusside-induced changes in arterial pressure (AP). Atropine and propranolol were used to measure cardiac autonomic tone. AP and pulse interval (PI) variability analysis were performed in the time and frequency domains (FFT spectral analysis) to evaluate cardiovascular sympatovagal modulation in WARs. AP and HR were higher in WARs (109 +/- 2 mm Hg and 366 +/- 9 bpm) than in Wistar control rats (101 +/- 2 mm Hg and 326 +/- 10 bpm). The power of the low-frequency band of both AP and PI spectra, a marker of sympathetic modulation, was higher in WARs than in Wistar control rats. The high-frequency power of the PI spectra in normalized units, which is linked to cardiac vagal modulation, was lower in WARS. Both WARs and Wistar control rats had similar vagal tone (91 +/- 13 bpm vs 94 +/- 11 bpm, respectively), but sympathetic tone was higher in WARS (30 +/- 4 bpm vs 14 +/- 4 bpm). No differences were detected in the gain of evoked (1.32 +/- 0.1 ms/mm Hg vs 135 +/- 0.2 ms/mm Hg) or spontaneous (1.34 +/- 0.2 ms/mm Hg vs 2.04 +/- 0.2 ms/mm Hg) baroreflex sensitivity. The higher AP and HR and the autonomic imbalance (sympathetic predominance) in WARs might be associated with an increased risk of life-threatening cardiovascular events in this strain. (C) 2011 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 07/50261-4 - Neurociências, epilepsia e arte: caracterização interdisciplinar da cepa WAR e modelos de epilepsia correlacionados: as oficinas Da Vinci, divulgação científica e quebras de estigmas em epilepsia
Beneficiário:Norberto Garcia Cairasco
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 05/56447-7 - Pesquisa através de imagens por ressonância magnética de alto campo destinadas a estudos em humanos
Beneficiário:João Pereira Leite
Linha de fomento: Auxílio à Pesquisa - Programa CINAPCE - Temático