Anxiolytic effects of erythrinian alkaloids from Erythrina mulungu

Autor(es)

Flausino Júnior, Otavio ; Santos, Luciana de Ávila ; Verli, Hugo ; Pereira, Ana Maria ; Bolzani, Vanderlan da Silva ^[5] ; Nunes-de-Souza, Ricardo Luiz

• Tipo de documento: Artigo Científico
• Fonte: Journal of Natural Products; v. 70, n. 1, p. 48-53, Jan. 2007.
• Área do conhecimento: Ciências Exatas e da Terra - Química
• Assunto(s): Fármacos Ansiolíticos Erythrina Espectroscopia de ressonância magnética nuclear

Resumo

One new erythrinian alkaloid derivative, (+)-11-hydroxyerythravine (1), and the known (+)-erythravine (2) and (+)--hydroxyerysotrine (3) were isolated from the flowers of Erythrina mulungu. Their structures were determined by spectroscopic/spectrometric data interpretation of 1H, 13C, and 2D NMR and MS experiments. The relative configuration was established by NOESY analysis, while the conformation adopted by these molecules was evaluated through molecular modeling studies and coupling constants obtained by NMR analysis. Furthermore, the anxiolytic effects of the E. mulungu aqueous alcoholic crude extract and of the purified alkaloids were evaluated using the elevated T-maze test. (AU)

• Processo FAPESP: 03/02176-7 - Conservação e uso sustentável da diversidade do Cerrado e da Mata Atlântica: diversidade química e prospecção de medicamentos potenciais - fase II
• Beneficiário: Vanderlan da Silva Bolzani
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático