Anxiolytic effects of erythrinian alkaloids from Erythrina mulungu

Author(s)

Flausino Júnior, Otavio ; Santos, Luciana de Ávila ; Verli, Hugo ; Pereira, Ana Maria ; Bolzani, Vanderlan da Silva ^[5] ; Nunes-de-Souza, Ricardo Luiz

• Document type: Journal article
• Source: Journal of Natural Products; v. 70, n. 1, p. 48-53, Jan. 2007.
• Field of knowledge: Physical Sciences and Mathematics - Chemistry

Abstract

One new erythrinian alkaloid derivative, (+)-11-hydroxyerythravine (1), and the known (+)-erythravine (2) and (+)--hydroxyerysotrine (3) were isolated from the flowers of Erythrina mulungu. Their structures were determined by spectroscopic/spectrometric data interpretation of 1H, 13C, and 2D NMR and MS experiments. The relative configuration was established by NOESY analysis, while the conformation adopted by these molecules was evaluated through molecular modeling studies and coupling constants obtained by NMR analysis. Furthermore, the anxiolytic effects of the E. mulungu aqueous alcoholic crude extract and of the purified alkaloids were evaluated using the elevated T-maze test. (AU)

• FAPESP's process: 03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II
• Grantee: Vanderlan da Silva Bolzani
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants