Defining the Molecular Basis of Tumor Metabolism: a Continuing Challenge Since Warburg's Discovery

Autor(es)

Santos de Souza, Ana Carolina ^[1] ; Justo, Giselle Zenker ^{[2, 3]} ; de Araujo, Daniele Ribeiro ^[1] ; Martins Cavagis, Alexandre D. ^[4]

Afiliação do(s) autor(es)

^[1] Univ Fed ABC UFABC, CCNH, Santo Andre - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Bioquim, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Dept Ciencias Biol, Sao Paulo - Brazil

^[4] Univ Fed Sao Carlos UFSCar, DFQM, Sorocaba - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY; v. 28, n. 5, p. 771-792, 2011.
• Citações Web of Science: 15

Resumo

Cancer cells are the product of genetic disorders that alter crucial intracellular signaling pathways associated with the regulation of cell survival, proliferation, differentiation and death mechanisms. The role of oncogene activation and tumor suppressor inhibition in the onset of cancer is well established. Traditional antitumor therapies target specific molecules, the action/expression of which is altered in cancer cells. However, since the physiology of normal cells involves the same signaling pathways that are disturbed in cancer cells, targeted therapies have to deal with side effects and multidrug resistance, the main causes of therapy failure. Since the pioneering work of Otto Warburg, over 80 years ago, the subversion of normal metabolism displayed by cancer cells has been highlighted by many studies. Recently, the study of tumor metabolism has received much attention because metabolic transformation is a crucial cancer hallmark and a direct consequence of disturbances in the activities of oncogenes and tumor suppressors. In this review we discuss tumor metabolism from the molecular perspective of oncogenes, tumor suppressors and protein signaling pathways relevant to metabolic transformation and tumorigenesis. We also identify the principal unanswered questions surrounding this issue and the attempts to relate these to their potential for future cancer treatment. As will be made clear, tumor metabolism is still only partly understood and the metabolic aspects of transformation constitute a major challenge for science. Nevertheless, cancer metabolism can be exploited to devise novel avenues for the rational treatment of this disease. Copyright (C) 2011 S. Karger AG, Basel (AU)

• Processo FAPESP: 10/16050-9 - Explorando a multifatoriedade da resistência a múltiplas drogas (MDR) em células tumorais: avaliação do papel desempenhado por proteínas tirosina fosfatases e alterações do metabolismo energético
• Beneficiário: Ana Carolina Santos de Souza Galvão
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/51116-0 - Potencial antileucêmico e mecanismos de ação de compostos bioativos em células primárias de leucemia mielóide aguda
• Beneficiário: Giselle Zenker Justo
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 10/11475-1 - Desenvolvimento e avaliação farmacológica de sistemas de liberação modificada contendo tramadol em hidrogéis termorreversíveis para o tratamento da dor
• Beneficiário: Daniele Ribeiro de Araujo
• Modalidade de apoio: Auxílio à Pesquisa - Regular