Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease

Autor(es)

Chaves de Souza, Joao Antonio ^[1] ; Rossa Junior, Carlos ^[1] ; Garlet, Gustavo Pompermaier ^[2] ; Boas Nogueira, Andressa Vilas ^[1] ; Cirelli, Joni Augusto ^[1]

Afiliação do(s) autor(es)

^[1] UNESP Univ Estadual Paulista, Dept Diag & Surg, Sch Dent, Araraquara, SP - Brazil

^[2] Univ Sao Paulo, Dept Biol Sci, Bauru Sch Dent, Bauru, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Applied Oral Science; v. 20, n. 2, p. 128-138, MAR-APR 2012.
• Citações Web of Science: 33

Resumo

Recently, new treatment approaches have been developed to target the host component of periodontal disease. This review aims at providing updated information on host-modulating therapies, focusing on treatment strategies for inhibiting signal transduction pathways involved in inflammation. Pharmacological inhibitors of MAPK, NFκB and JAK/STAT pathways are being developed to manage rheumatoid arthritis, periodontal disease and other inflammatory diseases. Through these agents, inflammatory mediators can be inhibited at cell signaling level, interfering on transcription factors activation and inflammatory gene expression. Although these drugs offer great potential to modulate host response, their main limitations are lack of specificity and developments of side effects. After overcoming these limitations, adjunctive host modulating drugs will provide new therapeutic strategies for periodontal treatment. (AU)

• Processo FAPESP: 07/06332-4 - Estudo da participação de reguladores negativos endógenos da atividade de STAT1 e STAT3 (SOCS-1, SOCS-3, PIAS1 e PIAS3) na Doença Periodontal Experimental
• Beneficiário: João Antonio Chaves de Souza
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 07/06658-7 - Estudo da participação de reguladores negativos endógenos da atividade de STAT1 e STAT3 (SOCS-1, SOCS-3, PIAS1 e PIAS3) na doença periodontal experimental
• Beneficiário: Joni Augusto Cirelli
• Modalidade de apoio: Auxílio à Pesquisa - Regular