Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease

Author(s)

Chaves de Souza, Joao Antonio ^[1] ; Rossa Junior, Carlos ^[1] ; Garlet, Gustavo Pompermaier ^[2] ; Boas Nogueira, Andressa Vilas ^[1] ; Cirelli, Joni Augusto ^[1]

Affiliation

^[1] UNESP Univ Estadual Paulista, Dept Diag & Surg, Sch Dent, Araraquara, SP - Brazil

^[2] Univ Sao Paulo, Dept Biol Sci, Bauru Sch Dent, Bauru, SP - Brazil

• Document type: Journal article
• Source: Journal of Applied Oral Science; v. 20, n. 2, p. 128-138, MAR-APR 2012.
• Web of Science Citations: 33

Abstract

Recently, new treatment approaches have been developed to target the host component of periodontal disease. This review aims at providing updated information on host-modulating therapies, focusing on treatment strategies for inhibiting signal transduction pathways involved in inflammation. Pharmacological inhibitors of MAPK, NFκB and JAK/STAT pathways are being developed to manage rheumatoid arthritis, periodontal disease and other inflammatory diseases. Through these agents, inflammatory mediators can be inhibited at cell signaling level, interfering on transcription factors activation and inflammatory gene expression. Although these drugs offer great potential to modulate host response, their main limitations are lack of specificity and developments of side effects. After overcoming these limitations, adjunctive host modulating drugs will provide new therapeutic strategies for periodontal treatment. (AU)

• FAPESP's process: 07/06332-4 - Role of endogenous negative regulators of STAT1 and STAT3 (SOCS-1, SOCS-3, PIAS1 and PIAS3) during experimental periodontal disease
• Grantee: João Antonio Chaves de Souza
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 07/06658-7 - Role of endogenous negative regulators of STAT1 and STAT3 (SOCS-1, SOCS-3, PIAS1 and PIAS3) during experimental periodontal disease
• Grantee: Joni Augusto Cirelli
• Support Opportunities: Regular Research Grants