VCD to determine absolute configuration of natural product molecules: secolignans from Peperomia blanda

Autor(es)

Felippe, Lidiane G. ^[1] ; Batista, Jr., Joao M. ^[1] ; Baldoqui, Debora C. ^[2] ; Nascimento, Isabele R. ^[1] ; Kato, Massuo J. ^[3] ; He, Yanan ^[4] ; Nafie, Laurence A. ^{[5, 4]} ; Furlan, Maysa ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Dept Organ Chem, Inst Chem, BR-14800900 Araraquara, SP - Brazil

^[2] Univ Estadual Maringa, Dept Chem, BR-87020900 Maringa, Parana - Brazil

^[3] Univ Sao Paulo, Dept Fundamental Chem, Inst Chem, BR-05508000 Sao Paulo, SP - Brazil

^[4] BioTools Inc, Jupiter, FL 33458 - USA

^[5] Syracuse Univ, Dept Chem, Syracuse, NY 13244 - USA

• Tipo de documento: Artigo Científico
• Fonte: ORGANIC & BIOMOLECULAR CHEMISTRY; v. 10, n. 21, p. 4208-4214, 2012.
• Citações Web of Science: 30

Resumo

The absolute configuration and solution-state conformers of three peperomin-type secolignans isolated from Peperomia blanda (Piperaceae) are unambiguously determined by using vibrational circular dichroism (VCD) spectroscopy associated with density functional theory (DFT) calculations. Advantages of VCD over the electronic form of CD for the analysis of diastereomers are also discussed. This work extends our growing knowledge about secondary metabolites within the Piperaceae family species while providing a definitive and straightforward method to assess the absolute stereochemistry of secolignans. (AU)

• Processo FAPESP: 08/58658-3 - Estudo químico e biológico de benzopiranos naturais em espécies de Piperaceae e seus análogos
• Beneficiário: João Marcos Batista Junior
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto