Protein domain connectivity and essentiality

Autor(es)

da F Costa‚ L. ; Rodrigues‚ F.A. ; Travieso‚ G.

• Tipo de documento: Artigo Científico
• Fonte: Applied Physics Letters; v. 89, n. 17, p. 174101-174101, 2006.

Resumo

Protein-protein interactions can be properly modeled as scale-free complex networks, while the lethality of proteins has been correlated with the node degrees, therefore defining a lethality-centrality rule. In this work the authors revisit this relevant problem by focusing attention not on proteins as a whole, but on their functional domains, which are ultimately responsible for their binding potential. Four networks are considered: the original protein-protein interaction network, its randomized version, and two domain networks assuming different lethality hypotheses. By using formal statistical analysis, they show that the correlation between connectivity and essentiality is higher for domains than for proteins. (c) 2006 American Institute of Physics. (AU)

• Processo FAPESP: 04/00492-1 - Caracterizacao, modelagem e simulacao de redes complexas.
• Beneficiário: Francisco Aparecido Rodrigues
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 99/12765-2 - Desenvolvimento e avaliação de métodos originais e precisos em análise de formas e imagens e visão computacional
• Beneficiário: Luciano da Fontoura Costa
• Modalidade de apoio: Auxílio à Pesquisa - Temático